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Method for preparing a ginkgo extract having a reduced content of 4'-o-methyl pyridoxine and/or biflavones

A technology of methylpyridoxine and ginkgo extract, which is applied in food preparation, medical raw materials derived from ginkgo biloba, drug combination, etc., can solve the problem that activated carbon cannot be regenerated

Active Publication Date: 2008-05-07
DR VILMAR SHVABE GMBKH EHND KO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this purpose activated carbon has the disadvantage that it usually does not bind in an extremely selective manner and cannot be regenerated

Method used

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  • Method for preparing a ginkgo extract having a reduced content of 4'-o-methyl pyridoxine and/or biflavones
  • Method for preparing a ginkgo extract having a reduced content of 4'-o-methyl pyridoxine and/or biflavones

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0053] Example 1 of the present invention (removes biflavones)

[0054] 25% of the original solution obtained above was applied to a column with 100 ml Sepabeads SP-850 sorbent resin and eluted with 300 ml 40 wt% ethanol. The eluate was concentrated under reduced pressure and freeze-dried: 11.5 g (23.0% as dry leaves).

example 2

[0055] Example 2 of the present invention (removal of 4'-O-methylpyridoxine)

[0056] 25% of the original solution obtained above was applied to a column with 20 ml of strongly acidic ion exchanger Amberlite IR-120 and eluted with 60 ml of 60% by weight ethanol. The eluate was concentrated under reduced pressure and freeze-dried: 13.0 g (26.0% as dry leaves).

example 3

[0057] Example 3 of the present invention (removal of biflavone and 4'-O-methylpyridoxine)

[0058] 25% of the original solution obtained above was applied to the first column with 100 ml of Sepabeads SP-850 sorbent resin and eluted with 300 ml of 40 wt% ethanol. The eluate was applied to a second column with 20 ml of strongly acidic ion exchanger Amberlite IR-120 and eluted with 100 ml of 40% by weight ethanol. The resulting solution was concentrated under reduced pressure and freeze-dried: 10.1 g (20.2% as dry leaves).

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Abstract

The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones comparing with the original extractive. The invention further relates to an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones comparing with the original extractive, which is obtainable by the method according to the present invention, as well as to its use.

Description

technical field [0001] The present invention relates to a process for the preparation of an extract of Ginkgo biloba having a reduced content of 4'-O-methylpyridoxine and / or biflavones compared to the original extract, characterized by the following process steps: [0002] (a) preparing a solution of Ginkgo biloba extract in a suitable solvent, and [0003] (b) applying the solution to an adsorbent resin and eluting the purified extract from the adsorbent resin using a suitable solvent, wherein the biflavone to be removed remains on the adsorbent resin, and / or [0004] (c) applying the solution to an acidic ion exchanger and eluting the purified extract from the ion exchanger using a suitable solvent, wherein the 4'-O-methylpyridoxine to be removed remains on the ion exchanger, and optionally , [0005] (d) concentrating and drying the extract solution to obtain a dry extract, [0006] Wherein steps (b) and (c) can also be carried out in reverse order. [0007] The present...

Claims

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Application Information

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IPC IPC(8): A61K36/00
CPCA23V2002/00A61K36/16A23L1/3002A23L33/105A61P25/28A61P9/00A23V2200/322A23V2250/2122A23V2200/326A61K31/4415A61K31/353
Inventor 克莱门斯·埃德尔迈尔荷尔曼·休格伊哥·酷克福瑞德须·朗卡尔-海兹·斯通姆普夫
Owner DR VILMAR SHVABE GMBKH EHND KO KG
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