Relieve asthma oral liquid preparation and preparing method thereof

An oral preparation and asthma technology, applied in the field of medicine, can solve the problems of inaccurate dosage, large dosage of traditional Chinese medicine decoction, and inability to commercialize it.

Inactive Publication Date: 2008-07-30
BEIJING JINFANGHUA MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The ancient Dingchuan Decoction only had decoctions, which needed to be decocted and taken after purchasing decoction pieces. It was very inconvenient to carry and take. After research, we made modern oral preparations of traditional Chinese medicine through quantitative control of index components. The product dosage is accurate, the quality is stable, and it is convenient to take. It is suitable for commercialized large-scale production, overcomes the shortcomings of traditional Chinese medicine decoctions such as large dosage, inaccurate dosage, inconvenient carrying and taking, and inability to commercialize, and is convenient for clinical treatment and home use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment one: Dingchuan decoction extract (extract and volatile oil) preparation method

[0048] Prescription: ginkgo 9g, ephedra 9g, perilla 6g, coltsfoot flower 9g, almond 9g, mulberry bark 9g, scutellaria baicalensis 4.5g, pinellia 9g, licorice 3g

[0049] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 10-15 times the amount of water to soak for 2-10 hours, heat and boil for 2-3 times, combine the extracts, collect volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to get the supernatant, concentrated under reduced pressure to obtain a medicinal extract of about 20.5 g of water extract and about 0.2 g of volatile oil.

Embodiment 2

[0050] Embodiment 2: Dingchuan Decoction oral solid preparation preparation method

[0051] (1) Preparation of Dingchuan Decoction Granules

[0052] prescription:

[0053] Dingchuan Decoction Extract 10-90%

[0054] Starch 5.0-70%

[0055] Dextrin 2.0-20%

[0056] Xylitol 5.0-20%

[0057] Methyl sorbate 0.001-2.0%

[0058] Preferred Prescription:

[0059] Dingchuan Decoction Extract 20.7g

[0060] Starch 8.0g

[0061] Dextrin 8.0g

[0062] Xylitol 4.0g

[0063] Methyl sorbate 0.002g

[0064] Preparation method: Prepare Chai Ding Chuan Decoction extract according to the method in Example 1, add the prescribed amount of auxiliary materials to make granules according to the conventional method, dissolve the volatile oil with an appropriate amount of ethanol, spray evenly on the granules, dry at low temperature, and pack. 10g per bag.

[0065] (2) Preparation of Dingchuan Decoction Effervescent Tablets

[0066] Prescription: Dingchuan Decoction Extract 20.7

[0067...

Embodiment 3

[0103] Embodiment three: Dingchuan decoction oral liquid preparation preparation method

[0104] (1) Preparation of oral liquid

[0105] Prescription: Dingchuan Decoction Extract 5-80%

[0106] Sucrose 5.0-50%

[0107] Sodium cyclamate 5.0-40%

[0108] Methyl sorbate 0.001-2%

[0109] Span 20 5.0-40%

[0110] Distilled water 10-90%.

[0111] Preferred Prescription:

[0112] Dingchuan Decoction Extract 20.7g

[0113] Sucrose 5.0g

[0114] Sodium cyclamate 1.5g

[0115] Span 20 2.5g

[0116] Methyl sorbate 0.02g

[0117] Make up to 60ml with distilled water.

[0118] Preparation method: prepare the extract of Dingchuan decoction according to the method in Example 1, add the excipients of the prescription and distilled water, then ultrafilter through an ultrafilter, fill the ultrafiltrate, and sterilize to obtain the product.

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Abstract

The invention relates to an oral preparation of asthma-relieving decoction which is prepared by ginkgo seeds and other eight Chinese medicines mainly for asthma treatment and the preparation method thereof; according to conventional processes, the invention is prepared by mixed tracts (extractum or dry powders and volatile oils), which are utilized as raw materials and formed by ginkgo seeds, ephedra, perilla fruits, coltsfoot flowers, almond, cortex mori, scutellaria, pinellia ternate and glycyrrhiza, together with the vectors or the excipient, which are utilized as matrix and acceptable in pharmacy. The preparation has the efficacies of ventilating lung, lowering qi, clearing away heat and eliminatingsputum and mainly treats wind and cold affecting superficies and ashma causing accumulation of phlegm-heat. The long-term clinical application shows that the oral preparation has a very good therapeutic effects on bronchial asthma and chronic bronchial asthma, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation of Dingchuan decoction for mainly treating asthma and a preparation method thereof, in particular to an oral preparation using the extract of traditional Chinese medicine Dingchuan decoction as the active ingredient. Background technique [0002] "Dingchuan Decoction" was created by Zhang Shiche in the Ming Dynasty in "Health-preserving All Wonders". Composed of white skin, scutellaria baicalensis, pinellia, and licorice, it has the effect of clearing lung and lowering qi, clearing heat and resolving phlegm, and mainly treating asthma syndrome with wind-cold external bundle and phlegm-heat internal accumulation. The long-term clinical application of the prescription shows that it has a good curative effect on bronchial asthma, chronic bronchial asthma, etc., and has wide application, and no obvious toxic and side effects have been found. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61K9/48A61K9/20A61K9/16A61K9/10A61K9/28A61K9/46A61K47/38A61K47/34A61K47/32A61P15/00A61P15/02A61K47/10
Inventor 张文芳
Owner BEIJING JINFANGHUA MEDICAL SCI TECH
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