Combined preparation of a thiazide diuretic and a loop diuretic

A technology of diuretics and thiazides, applied in the field of pharmaceutical preparations, can solve problems such as hyperkalemia, achieve the effects of prolonging the action time, preventing hypokalemia, and improving excretion

Inactive Publication Date: 2008-08-27
海因里希·克瑙夫
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this fixed combination also poses a problem due to the risk of hyperkalemia in patients with elevated plasma creatinine (and in older persons with pseudonormal plasma creatinine)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combined preparation of a thiazide diuretic and a loop diuretic
  • Combined preparation of a thiazide diuretic and a loop diuretic
  • Combined preparation of a thiazide diuretic and a loop diuretic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0037] 1. Method

[0038] The ethically justified experiments were performed in 12 healthy volunteers (age 28-48 years, 6 males, 6 females) who had given their written consent to the study. Prior to dosing, participants were clinically tested. Participants maintained a standard diet, receiving defined fluid (1.5 L / day) and salt intake (6 g NaCl; 100 mmol Na + / sky).

[0039] According to an earlier study (35), urine was collected prior to the treatment period, ie 24 hours to 12 hours and 12 hours to 0 hours (8 am) before oral administration. From this time point, urine was collected at 2-hour intervals until the 6th hour after administration, then from the 6th to the 9th hour, from the 9th to the 12th hour and from the 12th to the 24th hour. Samples of defined volumes during the respective collections were frozen and analyzed for Na using the "MODULAR" analyzer (Roche Comp., Switzerland). + 、K + , Cl - , Ca 2+ , Mg 2+ and creatinine.

[0040] All data are expressed as...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to pharmaceutical preparations which contain a combination of a thiazide diuretic and a low dose of a loop diuretic and which is particularly suitable for treating hypertension and heart failure. It is not only the natriuretic / diuretic effects which are increased due to said combination of thiazide diuretic and loop diuretic, but also the undesired secondary effects in relation to potassium and magnesium losses are also significantly reduced. As a result, the desired hypocalciuric effect of the thiazide is maintained despite the presence of the loop diuretic.

Description

technical field [0001] The present invention relates to pharmaceutical formulations containing a fixed combination of a low dose loop diuretic and a thiazide diuretic. Background technique [0002] Free combinations of loop diuretics / thiazide diuretics have been and are being used successfully in patients with so-called diuretic resistance (ie, patients in whom even high doses of loop diuretics are ineffective or insufficiently effective) , and in patients with severe renal failure. In 1971, the use of high-dose infusions of loop diuretics (eg, furosemide) in patients with severe cardiac disease with the addition of a thiazide diuretic (eg, chlorthalidone) was first reported. Re-establish diuresis in patients who no longer respond to treatment. In patients with severe renal disease, the combination of diuretics may reduce the often required ultra-high doses of loop diuretics and thus reduce the occurrence of side effects. However, in both cases, due to the risk of serious...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/64A61K31/549A61P7/10
CPCA61K31/549A61K31/64A61P7/10A61P9/00A61P9/04A61P9/12A61K2300/00
Inventor 海因里希·克瑙夫恩斯特·穆奇勒
Owner 海因里希·克瑙夫
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap