Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation for cefbuperazone sodium

A technology for cefrazone sodium and solution, which is applied in the field of preparation of cefrazone sodium, can solve the problems of high-cost freeze-drying equipment procurement investment and equipment maintenance investment, huge energy consumption, unfavorable sub-packaging and manufacturing, etc. The preparation conditions are not high, the operation method is simple, and the fluidity is good.

Inactive Publication Date: 2008-10-01
FUXIN BROAD PHARMA
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. The use of freeze-drying technology has high requirements for production equipment, and requires high-cost freeze-drying equipment purchase investment and equipment maintenance investment;
[0006] 2. The use of freeze-drying process will consume huge energy consumption and increase the production cost;
However, due to the poor stability of cefbuperazone sodium, the heat generated during the crushing process can lead to decomposition, resulting in the generation of impurities and a decrease in content, so it is difficult to obtain a material form with uniform particles and good fluidity for easy packaging
[0008] Based on above-mentioned shortcoming, adopt the preparation method of freeze-drying, both be unfavorable for large-scale and economical manufacture cefbuperazone sodium, adopt the product that this method obtains to be unfavorable for packaging and manufacture this product preparation again, therefore it is necessary to develop new method to solve the above-mentioned problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation for cefbuperazone sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Dissolve 10 grams of cefbuperazone sodium in 20 milliliters of water to prepare a cefbuperazone sodium solution. Under stirring at 20°C, the solution was added to 200 ml of ethanol, and a light yellow precipitate was precipitated. After filtering, the filter cake was vacuum-dried at room temperature to obtain 9 g of cefbuperazone sodium in the form of a light yellow solid powder, with an HPLC purity of 96.6%.

Embodiment 2

[0028] Dissolve 10 grams of cefbuperazone sodium in 20 milliliters of water to prepare a cefbuperazone sodium solution. Under stirring at 20°C, the solution was added to 200 ml of isopropanol, and a pale yellow precipitate was precipitated. After filtering, the filter cake was vacuum-dried at room temperature to obtain 8.9 g of cefbuperazone sodium in the form of a light yellow solid powder, with an HPLC purity of 97.6%.

Embodiment 3

[0030] Dissolve 10 grams of cefbuperazone sodium in 20 milliliters of water to prepare a cefbuperazone sodium solution. Under stirring at 20°C, the solution was added to 200 ml of acetone, and a pale yellow precipitate was precipitated. After filtration, the filter cake was vacuum-dried at room temperature to obtain 8 grams of cefbuperazone sodium in the form of a light yellow solid powder, with an HPLC purity of 96.4%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of Cefbuprazone Sodium, aiming at providing a method for preparing Cefbuprazone Sodium, which can substitute for the method of freezing and drying so as to be suitable for preparing Cefbuprazone Sodium economically in large scale. Solution which contains Cefbuprazone Sodium is added into a solvent, then obtaining the Cefbuprazone Sodium product after separation.

Description

field of invention [0001] The present invention relates to the preparation method of cefbuperazone sodium. The method can be used for large-scale industrial preparation of cefbuperazone sodium. Background of the invention [0002] Cefbuprazone Sodium (Cefbuprazone Sodium) is a cephamycin antibiotic developed by Japan Toyama Chemical Company and listed in 1985. Cefbuperazone Sodium has the chemical structure shown in the following formula: [0003] [0004] The cefbuperazone sodium that has been on the market is obtained by aseptic freeze-drying process, and the product is aseptically subpackaged into vials for medicinal use. In the published literature on the preparation method of this product, such as patent BE879217, the method of preparing this product is also aseptic freeze-drying. Prepare cefbuperazone sodium by the mode of aseptic freeze-drying, on large-scale industrial manufacture, there is following shortcoming: [0005] 1. The use of freeze-drying technology...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/57
Inventor 刘昆李彦高雪松刘佩华赵宁庞亚龙韩彦召王海贵
Owner FUXIN BROAD PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com