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Technique for preparing 5í»-inosine acid disodium

A technology of disodium inosinate and disodium inosinate water is applied in the field of production technology of disodium 5'-inosinate, which can solve the problems of unfavorable crystals, long time consumption, and high temperature of solution, and improve yield and purity , the effect of reducing production costs

Active Publication Date: 2008-10-29
肇东星湖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The whole process takes a long time, and the crystallization of the solution is slow. In addition, the temperature of the solution is high during the proce

Method used

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  • Technique for preparing 5í»-inosine acid disodium

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Take 200ml of the aqueous phase of disodium 5′-inosinate, add BaCl 2 Solution (saturated or nearly saturated) 300ml, while stirring, add membrane alkali to neutralize to PH7.3-7.6, or add alkali to neutralize to PH7.3-7.6, add BaCl 2 Solution (saturated or nearly saturated) 300ml, stirring precipitation, normal temperature, time 5 minutes, vacuum suction filtration with Buchner funnel filter paper, obtain mother liquor and IMPBa salt, calculate mother liquor loss rate, add IMPBa salt to Na 2 SO 4 Solution (saturated or nearly saturated) to 200ml, stirred at 60°C for 3 hours, disodium 5'-inosinate was precipitated, vacuum filtered with Buchner funnel filter paper at 60°C, filtration rate 5L / m 2 h, get BaSO 4 Precipitate and filtrate, calculate the yield of disodium 5'-inosinate in the filtrate and measure the purity.

Embodiment 2

[0010] Take 200ml of the aqueous phase of disodium 5′-inosinate, add BaCl 2 Solution (saturated or nearly saturated) 300ml, while stirring, add membrane alkali to neutralize to PH7.3-7.6, or add alkali to neutralize to PH7.3-7.6, add BaCl 2 Solution (saturated or nearly saturated) 300ml, stirred and precipitated, 0 ℃, time 5 minutes, with Buchner funnel filter paper vacuum filtration, get mother liquor and IMPBa salt, calculate mother liquor loss rate, add IMPBa salt to Na 2 SO 4 Solution (saturated or nearly saturated) to 200ml, stirred at 60°C for 20 minutes, disodium 5'-inosinate was precipitated, vacuum filtered with Buchner funnel filter paper at 60°C, filtration rate 5L / m 2 h, get BaSO 4 Precipitate and filtrate, calculate the yield of disodium 5'-inosinate in the filtrate and measure the purity.

Embodiment 3

[0012] Take 200ml of the aqueous phase of disodium 5′-inosinate, add BaCl 2 Solution (saturated or nearly saturated) 300ml, while stirring, add membrane alkali to neutralize to PH7.3-7.6, or add alkali to neutralize to PH7.3-7.6, add BaCl 2 Solution (saturated or nearly saturated) 300ml, stirred and precipitated, cooled to below 10°C for 40 minutes, vacuum filtered with Buchner funnel filter paper to obtain mother liquor and IMPBa salt, calculate mother liquor loss rate, add IMPBa salt to Na 2 SO 4 Solution (saturated or nearly saturated) to 200ml, stirred at room temperature for 20 minutes, precipitated disodium 5'-inosinate, vacuum filtered with Buchner funnel filter paper, filter speed 5L / m 2 h, get BaSO 4 Precipitate and filtrate, calculate the yield of disodium 5'-inosinate in the filtrate and measure the purity.

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Abstract

The invention relates to a production process of 5'-disodium inosinate, particularly to a production process of 5'-disodium inosinate by barium (Ba) precipitation. The production process comprises the steps of: collecting 5'-disodium inosinate water phase, adding certain 5'-disodium inosinate equivalent times of BaCl2 solution (saturated or nearly saturated), adding membrane caustic soda or alkali under stirring to neutralize to pH 7.3-7.6, adding certain 5'-disodium inosinate equivalent times of BaCl2 solution (saturated or nearly saturated), stirring, allowing precipitation, cooling down to below 10 DEG C, performing vacuum filtration with a Buchner funnel filter paper to obtain a mother liquid and a barium inosinate (IMPBa) salt, calculating mother liquid loss rate, adding the IMPBa salt into NaSP4 solution (saturated or nearly saturated) with certain equivalent times of 5'-disodium inosinate in the 5'-disodium inosinate water phase, stirring at 60-70 DEG C to precipitate inosinate (IMP), performing vacuum filtration with a Buchner funnel filter paper at 60-70 DEG C to obtain a BaSO4 precipitate and a filtrate, and calculating 5'-disodium inosinate yield and purity of 5'-disodium inosinate in the filtrate. Compared with the prior art, the inventive production process has the advantages of improved yield and purity of 5'-disodium inosinate, and reduced production cost.

Description

technical field [0001] The invention relates to a production process of 5'-disodium inosinate, in particular to a production process of obtaining 5'-disodium inosinate through a Ba precipitation process. Background technique [0002] 5'-inosinic acid (5'-IMP) is an intermediate substance of nucleic acid biosynthetic metabolic system, which is used in various fields, such as food and medicine, and various medical fields. 5'-inosinic acid (5'-IMP) is non-hygroscopic, soluble in water and stable in aqueous solution. In acidic solution, it is easy to decompose at high temperature and can be decomposed and destroyed by phosphatase. It is slightly soluble in ethanol and almost insoluble in ether. When JECFA re-evaluated in 1993, disodium 5′-inosinate was non-carcinogenic, teratogenic, and harmless to reproduction. Moreover, it is one of the nucleic acid condiments. In addition to its umami taste, its sodium salt has a synergistic effect when mixed with sodium glutamate. Bittern...

Claims

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Application Information

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IPC IPC(8): C07H19/20
Inventor 张逸伟刘剑潘小锋伍文锋瞿东方顾振东梁健富宁异真
Owner 肇东星湖生物科技有限公司
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