Chinese herbal medicine compound preparation for treating hypertension and its preparation method

A compound preparation and high blood pressure technology, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of inconvenient carrying, difficult quality control, and large dosage, so as to improve curative effect and improve reconstruction Circumstances, the effect of a reasonable combination

Inactive Publication Date: 2012-03-14
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The theoretical research of traditional Chinese medicine shows that "yang hyperactivity" and "blood stasis" are the basic pathological links in the pathogenesis of hypertension. The existing technology of this medicine uses Chinese herbal medicines such as salvia miltiorrhiza and tribulus terrestris to make decoction to treat mild to moderate essential hypertension. disease (blood stasis and yang hyperactivity syndrome), there are deficiencies such as taking, inconvenient to carry, difficult to control the quality, and excessive daily dosage

Method used

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  • Chinese herbal medicine compound preparation for treating hypertension and its preparation method
  • Chinese herbal medicine compound preparation for treating hypertension and its preparation method
  • Chinese herbal medicine compound preparation for treating hypertension and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Extraction Technology Research

[0012] Medicinal materials and reference substances:

[0013] Salvia miltiorrhiza, Tribulus terrestris, Tribulus terrestris (Shayuanzi), Alisma, Qinglizi and other five medicinal materials were purchased from Shanghai Kangqiao Chinese Herbal Pieces Co., Ltd., and were identified to meet the requirements of the Chinese Pharmacopoeia;

[0014] Danshensu Sodium: (batch number 110855-200203) was purchased from China Institute for the Identification of Pharmaceutical and Biological Products;

[0015] Rutin: (batch number) purchased from China National Institute of Pharmaceutical and Biological Products.

[0016] Reagent: medical 95% ethanol lot number A2-54 (Shanghai Zhenxing Chemical Factory No. 1); methanol: chromatographic grade; distilled water.

[0017] Instrument: Matou brand JYT-10 drug balance (Shanghai Medical Laser Instrument Factory);

[0018] HHSO-2 type electric constant temperature water bath (Shanghai No. 5 Medical...

Embodiment 2

[0053] Embodiment 2 dosage form selection

[0054] Adopt optimal process to extract 3 parts, each part is half the amount (25.5g) of the prescription and after reclaiming ethanol, be settled in the 50ml volumetric flask with distilled water. Precisely pipette 10ml of the drug solution from the above three samples respectively, put them in three dried evaporating dishes with constant weight, bathe in water until dry, and then put them in an oven to constant weight. Calculate the ointment rate. Table 7 is the calculation of the paste yield of the preferred process.

[0055] Table 7

[0056]

[0057] Calculate the daily dosage according to the ointment rate = 51g×14.15%=7.2g, add more than 10g after adding auxiliary materials, estimate according to 0.5g per tablet or capsule, then you need to take more than 20 tablets (grains) per day, greatly Beyond people's daily medication habits. Tablets and capsules cannot be made, so granules are selected.

[0058] Particle check: ...

Embodiment 3

[0076] Embodiment 3 granule quality standard research

[0077] Content Determination of Active Components in Salvia Miltiorrhiza:

[0078] 1. Determination of Tanshinone II A content

[0079] (1) Chromatographic conditions and system adaptability test:

[0080] Use octadecylsilane bonded silica gel as filler; methanol-water (15:5) as mobile phase; detection wavelength λ270nm; theoretical plate number should not be less than 2000 based on tanshinone II A peak.

[0081] (2) Preparation of reference substance solution:

[0082] Weigh 2.55mg of Tanshinone II A reference substance, put it in a 25ml brown volumetric flask, add methanol to the mark, and shake well; accurately measure 1ml, put it in a 10ml brown volumetric flask, add methanol to the mark, shake well, and you get it. (Every 1ml contains tanshinone II A10.2μg).

[0083] (3) Preparation of the test solution:

[0084] Take 0.3g of Salvia miltiorrhiza medicinal material powder (passed through No. 3 sieve), accurately ...

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Abstract

The invention belongs to the field of a Chinese traditional medicine, in particular to a Chinese traditional compound preparation used for curing hypertension, and a method for preparing the Chinese traditional compound preparation. The compound preparation is prepared from Chinese traditional medicaments, such as radix salviae miltiorrhizae, fructus tribuli, flatstem milkvetch seed, alisma orientale and feather cockscomb seed by adopting the extraction process of optimal granules through orthogonal design experiments. The preparation is capable of promoting blood circulation by removing blood stasis and restraining the hyperactivity of the liver yang with reasonable ingredients. Proven through animal experiments and clinical research, the preparation can significantly improve such clinical symptoms as dizziness, headache, vexation vexation, insomnia, numb limbs, soreness and weakness of waist and knees, dark purple texture of tongue and petechia of body of tongue and so on; can effectively prevent the target organs from being injured resulting from hypertension, and can improve the reconstruction of hypertensive blood vessels to some extent, and can further improve the curative effect of Chinese traditional medicaments on hypertension and complications thereof.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound traditional Chinese medicine preparation for treating hypertension and a preparation method thereof. Background technique: [0002] Hypertension is one of the common cardiovascular diseases. Studies have reported that hypertension is closely related to coronary atherosclerotic heart disease and cerebrovascular diseases, and it is still one of the main causes of death in cardiovascular diseases so far. Although modern medicine has made great progress, in recent years, with the progress of large-scale antihypertensive clinical trials and basic research on cardiovascular molecular biology, people have gradually realized that hypertension is not just a disease of hemodynamic abnormalities , or a variety of cardiovascular risk factors aggregation, genetic syndrome. Therefore, in terms of treatment, it is not only necessary to reduce blood pressure t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K9/16A61P9/12
Inventor 周端魏莉杨建梅王佑华肖梅芳顾仁樾王志
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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