Chinese herbal medicine compound preparation for treating hypertension and its preparation method
A compound preparation and high blood pressure technology, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of inconvenient carrying, difficult quality control, and large dosage, so as to improve curative effect and improve reconstruction Circumstances, the effect of a reasonable combination
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Embodiment 1
[0011] Example 1 Extraction Technology Research
[0012] Medicinal materials and reference substances:
[0013] Salvia miltiorrhiza, Tribulus terrestris, Tribulus terrestris (Shayuanzi), Alisma, Qinglizi and other five medicinal materials were purchased from Shanghai Kangqiao Chinese Herbal Pieces Co., Ltd., and were identified to meet the requirements of the Chinese Pharmacopoeia;
[0014] Danshensu Sodium: (batch number 110855-200203) was purchased from China Institute for the Identification of Pharmaceutical and Biological Products;
[0015] Rutin: (batch number) purchased from China National Institute of Pharmaceutical and Biological Products.
[0016] Reagent: medical 95% ethanol lot number A2-54 (Shanghai Zhenxing Chemical Factory No. 1); methanol: chromatographic grade; distilled water.
[0017] Instrument: Matou brand JYT-10 drug balance (Shanghai Medical Laser Instrument Factory);
[0018] HHSO-2 type electric constant temperature water bath (Shanghai No. 5 Medical...
Embodiment 2
[0053] Embodiment 2 dosage form selection
[0054] Adopt optimal process to extract 3 parts, each part is half the amount (25.5g) of the prescription and after reclaiming ethanol, be settled in the 50ml volumetric flask with distilled water. Precisely pipette 10ml of the drug solution from the above three samples respectively, put them in three dried evaporating dishes with constant weight, bathe in water until dry, and then put them in an oven to constant weight. Calculate the ointment rate. Table 7 is the calculation of the paste yield of the preferred process.
[0055] Table 7
[0056]
[0057] Calculate the daily dosage according to the ointment rate = 51g×14.15%=7.2g, add more than 10g after adding auxiliary materials, estimate according to 0.5g per tablet or capsule, then you need to take more than 20 tablets (grains) per day, greatly Beyond people's daily medication habits. Tablets and capsules cannot be made, so granules are selected.
[0058] Particle check: ...
Embodiment 3
[0076] Embodiment 3 granule quality standard research
[0077] Content Determination of Active Components in Salvia Miltiorrhiza:
[0078] 1. Determination of Tanshinone II A content
[0079] (1) Chromatographic conditions and system adaptability test:
[0080] Use octadecylsilane bonded silica gel as filler; methanol-water (15:5) as mobile phase; detection wavelength λ270nm; theoretical plate number should not be less than 2000 based on tanshinone II A peak.
[0081] (2) Preparation of reference substance solution:
[0082] Weigh 2.55mg of Tanshinone II A reference substance, put it in a 25ml brown volumetric flask, add methanol to the mark, and shake well; accurately measure 1ml, put it in a 10ml brown volumetric flask, add methanol to the mark, shake well, and you get it. (Every 1ml contains tanshinone II A10.2μg).
[0083] (3) Preparation of the test solution:
[0084] Take 0.3g of Salvia miltiorrhiza medicinal material powder (passed through No. 3 sieve), accurately ...
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