Antrodia camphorate pimelie kelone compounds for releasing physiological fatigue

A technology of cyclohexenone and compounds, applied in the field of cyclohexenone compounds, can solve the problems of publication and lack of specific relevant active ingredients, etc., achieve the effect of improving central fatigue and peripheral fatigue, and slowing down muscle cell damage

Inactive Publication Date: 2008-12-31
GOLDEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although it can be known from many current experiments that the extract of Antrodia Cinnamomea has the aforementioned effects, and its components have been analyzed one after another, there is no specific correlation as to which active ingredients in the extract can contribute to these effects of Antrodia Cinnamomum. The active ingredients were published, and the anti-fatigue ingredients contained in the Antrodia camphorata extract need further experimental research to clarify, so if we can find out the truly effective anti-fatigue ingredients contained in the extract, it will be beneficial to the research on the anti-fatigue of Antrodia camphorata The related mechanism of Antrodia Cinnamomea is of great help in alleviating physiological fatigue in the human body

Method used

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  • Antrodia camphorate pimelie kelone compounds for releasing physiological fatigue
  • Antrodia camphorate pimelie kelone compounds for releasing physiological fatigue
  • Antrodia camphorate pimelie kelone compounds for releasing physiological fatigue

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 4-Hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-2,6,10-dodecatriene)-2-cyclohexenone separate

[0026] Put about 100 grams of Antrodia mycelium, fruiting bodies or a mixture of the two into a conical flask, add an appropriate proportion of water and alcohols (for example, an aqueous alcohol solution of more than 70%), and store at 20-25 ° C. Stir and extract for at least 1 hour, then filter through filter paper and a 0.45 μm filter membrane to collect the extract.

[0027] The Antrodia camphorata extract collected above was analyzed using a high performance liquid chromatography (High Performance Liquid chromatography) with an RP18 column (column), and methanol (A) and 0.1%-0.5% acetic acid aqueous solution (B) were used as the flow Phase (mobile phase) (the solution ratio is: 0-10 minutes, B ratio is 95%-20%; 10-20 minutes, B ratio is 20%-10%; 20-35 minutes, B ratio is 10%- 10%; 35-40 minutes, the B ratio is 10%-95%), eluted at a speed of 1 ml per minute, and sim...

Embodiment 2

[0029] Example 2: 80% maximal oxygen uptake (80% VO 2 max) exercise load test

[0030] In order to measure the effect of supplementing Antrodia antrodia cyclohexenone compound on the anti-fatigue ability after exhaustive exercise, this experiment uses 80% of the maximum oxygen uptake exercise load to carry out subsequent exhaustion exercise, so the maximum oxygen uptake must be measured first to further Extrapolate the rate at 80% of your VO2max. Among them, oxygen uptake refers to the product of cardiac output and the difference between arterial and venous blood oxygen concentration, and maximal oxygen uptake refers to the amount that tissue cells can consume or utilize per minute when a person engages in the most strenuous exercise at sea level. The highest value of oxygen, which is the best index for evaluating cardiorespiratory endurance, the present invention is based on the direct measurement method in the laboratory, using the in-situ treadmill, to gradually increase t...

Embodiment 3

[0040] Embodiment 3: Anti-fatigue test of Antrodia antrodia cyclohexenone compound

[0041] The broad definition of muscle fatigue during exercise is that the individual physiological process cannot maintain its function at a certain level, or each organ cannot maintain the predetermined exercise intensity. The causes of physical activity fatigue can include three aspects: psychology, physiology and biochemistry. Potential mechanisms include both central and peripheral fatigue. The mechanisms that cause central fatigue include hypoglycemia, changes in the concentration of key amino acids in the blood, and changes in the concentration of neurotransmitters in the brain, while the mechanisms of peripheral fatigue include phosphoric acid in the muscles. Creatine (phospocreatine; PC) depletion leads to increased blood ammonia, muscle glycogen depletion and insufficient oxygen supply and other energy shortages, as well as metabolites such as lactic acid increase and muscle phosphate ...

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Abstract

The invention relates to an Antrodia cinnamomea compound which can slow down physiological fatigue, in particular to a 4-hydroxy -2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone separated from the extract of Antrodia cinnamomea, which can effectively slow down the physiological fatigue. In the invention, after 80% of maximal oxygen uptake of high-intensity exhausted exercises, the application of the compound can promote the metabolism of creatine kinase and blood ammonia in the body and contribute to the restoration of the concentration to achieve the effect of slowing down the physical fatigue.

Description

technical field [0001] The present invention relates to a compound for anti-fatigue, in particular to a cyclohexenone compound prepared by separating and purifying antrodia camphorata extract and used for alleviating physiological fatigue. Background technique [0002] Antrodia camphorata (Antrodia camphorata), also known as Antrodia camphorata, Antrodia camphorata, or Antrodia red, belongs to the perennial fungus of the family Polyporaceae in the order Aphyllophorales. It is a unique fungus in Taiwan and only grows in Taiwan. On the inner wall of the hollow decaying heartwood of the conservation tree species-Cinnamoum kanehirai Hay. Due to the extremely rare distribution of Cinnamomum camphora and human-made poaching, the number of wild Antrodia camphorata parasitic in it is even rarer, and because its fruiting body grows very slowly, the growth period is only between June and October. , and therefore very expensive. [0003] The fruiting body of Antrodia cinnamomea is pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/753C07C45/80A61K31/122A61P43/00
CPCA61K36/07A61P35/00A61P43/00C07C49/753C07C323/22
Inventor 刘胜勇温武哲郭茂田
Owner GOLDEN BIOTECH
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