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Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould

A stimulation electrode, multi-site technology, applied in the field of biomedical engineering, can solve problems such as mis-stimulation of functional nuclei, adjustment of stimulation areas that cannot be electrodes, and difficulty in integrating a large number of channels at the electrode end, achieving precise stimulation positioning, high stimulation Precision, effects of multiple stimulation modes

Active Publication Date: 2009-01-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this kind of electrode are: 1. The stimulation accuracy of the electrode is low. For the ring electrode, the diameter of the stimulation area is close to 3-4 mm, which is easy to exceed the functional nucleus area, resulting in false stimulation of the surrounding functional nucleus.
2. Unable to cope with electrode displacement. Once the electrode is displaced, the stimulation area of ​​the electrode cannot be adjusted, which may easily cause false stimulation
3. The number of channels is small. For ring electrodes, due to the simple arrangement of electrode stimulation points, it is difficult to integrate multiple channels at the end of the electrode.

Method used

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  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould
  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould
  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould

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Experimental program
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Effect test

Embodiment 1

[0035] Such as figure 1 As shown, this embodiment includes a stimulation electrode sheet 1, an electrode lead 2, an electrode interface 3, and a stimulation node 4. The entire stimulation electrode is provided with multiple stimulation electrode sheets 1 at the same depth, and each stimulation electrode sheet 1 passes through its own separate The electrode lead 2 is connected to the electrode interface 3, a plurality of stimulation electrode sheets 1 are formed into a cylindrical stimulation node 4, two or more than two groups of stimulation nodes 4 are plasticized and connected with biocompatible silica gel 5 to form an electrode. Array, the electrode array is located at the front end of the entire stimulation electrode.

[0036] The stimulation electrode sheet 1 is made of a platinum-iridium alloy with biocompatibility.

[0037] Such as Figure 5 As shown, the stimulation electrode sheet 1 is connected to the electrode interface needle 6 of the electrode interface 3 by a separa...

Embodiment 2

[0049] Such as Figure 7 As shown, the injection mold 13 used to prepare the above-mentioned electrode array has electrode embedding points 14 whose arrangement forms are arranged according to design requirements. The angle and arc length of the embedding point are equivalent to the outer arc column of the stimulation electrode sheet 1, and the arc column thickness of the stimulation electrode sheet 1 exposed to the encapsulated silica gel 5 is ΔR. The distance between adjacent embedding points is L3, and the length of the stimulation area at the end of the electrode is L2.

[0050] The injection mold 13 has two ends open, one end is used as a wire entry end, and the other end is injected with biocompatible silica gel 5, and there is an inner core 15 in the middle of the injection mold 13.

[0051] The inner core 15 of the injection mold is surrounded by several arc columns to form a cylindrical mold. The number of arc columns is equal to the number of stimulation electrode sheets...

Embodiment 3

[0053] The material used to make DBS deep brain multi-channel stimulation electrode is a platinum-iridium alloy with biocompatibility. The platinum-iridium alloy sheet is cut into two combined concentric arc columns according to the design specifications. The large arc column is used as the embedding support point of the stimulation site, and it is completely wrapped by the biocompatible silica gel; the small arc The part of the column exposed outside the insulating layer is an electrical stimulation site that directly contacts the tissue; at the same time, a small groove is left on the inner side of the large arc column as a welding point 10 of the wire. The angle α and radius r of the arc column are determined according to the number of stimulation electrode sheets in the same set of stimulation nodes and the electrode radius. The height of the outer arc column is h1, and the height of the inner arc column is h2. Here, taking 4 stimulation electrode sheets 1 to form a stimulatio...

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Abstract

The invention discloses a multi-site stimulating electrode array for brain stimulation, which belongs to the technical field of biomedical engineering, and an electrode interface and a plastic casting mold for the same. The electrode array comprises stimulating electrode plates, electrode wires, an electrode interface, and stimulating nodes. The multiple stimulating electrode plates are arranged at the same depth in total stimulating electrode. Each stimulating electrode plate is connected to the electrode interface via respective and individual electrode wires. The stimulating electrode plates are enclosed to form the columnar stimulating nodes. At least two or more groups of the stimulating nodes are connected by silica gel plastic package with the biocompatibility to form the electrode array. The male interface of the electrode interface is connected to one end of the stimulating electrode plates, and the female interface of the electrode interface is connected to one end of a stimulator. The plastic casting mold has openings at two ends, wherein one end is taken as the inlet end of the wires, and the other end is used for casting the silica gel having the biocompatibility, and an inner core is arranged in the middle of the mold. With the multi-site stimulating electrode array, the contradiction between the electrode size limit and the stimulating passage multiplexing is solved, and the three dimension of a stimulation manner and the optimization of a stimulating region are ensured.

Description

Technical field [0001] The invention relates to an electrode and its interface and mold in the technical field of biomedical engineering, and in particular to a multi-point stimulation electrode array for brain stimulation, its electrode interface and a potting mold. Background technique [0002] At present, the deep brain stimulator (DBS) has been used in the treatment of central nervous system diseases such as Parkinson's disease, essential tremor, epilepsy, chorea, obsessive-compulsive disorder, and torsion spasm. As a kind of non-destructive treatment, deep brain stimulators have made great progress in recent years. In the treatment of Parkinson's disease, patients have been able to return to normal life and have also achieved significant results in the treatment of other diseases. The advantage is that the stimulation signal can be adjusted according to the severity of the disease, and the damage to the nerve nucleus is small and reversible. [0003] When the brain depth sti...

Claims

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Application Information

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IPC IPC(8): A61N1/05A61N1/02
Inventor 吴开杰任秋实王洪良陆一樑孙伯民
Owner SHANGHAI JIAO TONG UNIV
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