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Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould

A stimulation electrode, multi-site technology, applied in the field of biomedical engineering, can solve the problems of adjusting the stimulation area of ​​the electrode, the difficulty of integrating a large number of channels at the electrode end, and the mis-stimulation of functional nuclei. Effects of stimulus patterns, precise stimulus localization

Active Publication Date: 2010-07-21
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this kind of electrode are: 1. The stimulation accuracy of the electrode is low. For the ring electrode, the diameter of the stimulation area is close to 3-4 mm, which is easy to exceed the functional nucleus area, resulting in false stimulation of the surrounding functional nucleus.
2. Unable to cope with electrode displacement. Once the electrode is displaced, the stimulation area of ​​the electrode cannot be adjusted, which may easily cause false stimulation
3. The number of channels is small. For ring electrodes, due to the simple arrangement of electrode stimulation points, it is difficult to integrate multiple channels at the end of the electrode.

Method used

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  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould
  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould
  • Multi-site stimulating electrode array for brain stimulation and electrode interface thereof, irrigation mould

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Experimental program
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Effect test

Embodiment 1

[0035] Such as figure 1 As shown, this embodiment includes a stimulating electrode sheet 1, an electrode wire 2, an electrode interface 3, and a stimulating node 4. The entire stimulating electrode is provided with a plurality of stimulating electrode sheets 1 at the same depth, and each stimulating electrode sheet 1 passes through a separate The electrode wires 2 are connected to the electrode interface 3, and a plurality of stimulating electrode sheets 1 form a columnar stimulating node 4, and two or more groups of stimulating nodes 4 are plastic-sealed and connected with biocompatible silica gel 5 to form an electrode Array, the electrode array is located at the front end of the entire stimulating electrode.

[0036] The stimulating electrode sheet 1 is made of biocompatible platinum-iridium alloy.

[0037] Such as Figure 5 As shown, the stimulating electrode sheet 1 is connected to the electrode interface pin 6 of the electrode interface 3 by a separate electrode wire 2...

Embodiment 2

[0049] Such as Figure 7 As shown, the potting mold 13 used to prepare the above-mentioned electrode array has electrode embedding points 14 arranged according to design requirements. The angle and arc length of the embedding point are equivalent to the outer arc column of the stimulating electrode sheet 1, and the arc column thickness of the stimulating electrode sheet 1 exposing the packaging silicone 5 is ΔR. The distance between adjacent embedding points is L3, and the length of the stimulation area at the end of the electrode is L2.

[0050] The filling mold 13 has openings at both ends, one end is used as the wire entry end, and the other end is filled with biocompatible silica gel 5 , and there is an inner core 15 in the middle of the filling mold 13 .

[0051] The inner core 15 of the injection mold is surrounded by several arc columns to form a cylindrical mold. The number of arc columns is equal to the number of stimulating electrode sheets 1 forming one stimulatin...

Embodiment 3

[0053] The material used to make DBS deep brain multi-channel stimulation electrodes is a biocompatible platinum-iridium alloy. The platinum-iridium alloy sheet is cut into two joint concentric arc columns according to the design specifications. The large arc column is used as the embedded support point of the stimulation site, and it is completely covered by using biocompatible silicone; the small arc column The part of the column exposed outside the insulating layer is the electrical stimulation site for direct contact with the tissue; meanwhile, a small groove is left on the inner side of the large arc column as a welding point 10 for the wire. The angle α and radius r of the arc column are determined according to the number of stimulating electrode sheets in the same group of stimulating nodes and the radius of the electrode. The height of the outer arc column is h1, and the height of the inner arc column is h2. Here, four stimulating electrode sheets 1 form a stimulating ...

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Abstract

The invention discloses a multi-site stimulating electrode array for brain stimulation, which belongs to the technical field of biomedical engineering, and an electrode interface and a plastic casting mold for the same. The electrode array comprises stimulating electrode plates, electrode wires, an electrode interface, and stimulating nodes. The multiple stimulating electrode plates are arranged at the same depth in total stimulating electrode. Each stimulating electrode plate is connected to the electrode interface via respective and individual electrode wires. The stimulating electrode plates are enclosed to form the columnar stimulating nodes. At least two or more groups of the stimulating nodes are connected by silica gel plastic package with the biocompatibility to form the electrodearray. The male interface of the electrode interface is connected to one end of the stimulating electrode plates, and the female interface of the electrode interface is connected to one end of a stimulator. The plastic casting mold has openings at two ends, wherein one end is taken as the inlet end of the wires, and the other end is used for casting the silica gel having the biocompatibility, andan inner core is arranged in the middle of the mold. With the multi-site stimulating electrode array, the contradiction between the electrode size limit and the stimulating passage multiplexing is solved, and the three dimension of a stimulation manner and the optimization of a stimulating region are ensured.

Description

technical field [0001] The invention relates to an electrode, its interface and a mould, in the technical field of biomedical engineering, in particular to a multi-site stimulating electrode array for brain stimulation, its electrode interface, and a plastic injection mould. Background technique [0002] At present, the deep brain stimulator (DBS) has been used in the treatment of central nervous system diseases such as Parkinson's disease, essential tremor, epilepsy, chorea, obsessive-compulsive disorder, and torsional spasm. As a non-destructive treatment, deep brain stimulators have made great progress in recent years. In the treatment of Parkinson's disease, patients have been able to return to normal life, and the treatment of other diseases has also achieved obvious results. The advantage is that the stimulation signal can be adjusted according to the severity of the disease, and the damage to the nerve nucleus is small and reversible. [0003] When the deep brain sti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/05A61N1/02
Inventor 吴开杰任秋实王洪良陆一樑孙伯民
Owner SHANGHAI JIAOTONG UNIV
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