Computation method for annotating semantic similarity by gene

A technology of semantic similarity and calculation method, applied in the field of gene annotation semantic similarity calculation, can solve the problem that the hierarchical decreasing ratio is difficult to determine, there is no accurate calculation of gene annotation semantic similarity, and node semantic similarity cannot be calculated. Reuse, etc.
CN101359349AInactive Publication Date: 2009-02-04SHANGHAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI UNIV
Publication Date
2009-02-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a computation method of gene annotation semantic similarity. The method establishes correlation between the gene and the gene body node through the gene body correlation file provided by the gene body association; then the semantic similarity of the gene body node is firstly computed; the gene annotation semantic similarity is computed finally according to the semantic similarity of the gene body node. The computation method has the advantages of computing the gene annotation semantic similarity automatically and in large quantity.
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Description

technical field

[0001] The invention relates to a method for calculating the semantic similarity of gene annotation, which belongs to the technical field of bioinformatics. Background technique

[0002] Gene ontology (gene ontology, GO) is an important gene annotation database, and biologists often use online tools such as AmiGO and QuickGO to retrieve gene GO annotations. After obtaining the gene annotations, it is necessary to compare the similarity of the semantics of the gene annotations, that is, to examine whether the functions of some genes are similar, or whether some genes are jointly involved in the metabolic process of certain substances, etc. At present, comparing the similarity of genes is mainly done manually. Since biologists usually need to compare dozens or even hundreds of genes, it will be very time-consuming and labor-intensive to compare the similarity of so many genes manually. , and the manual comparison will also be affected by subjective factors. U...

Claims

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