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Method and device for measuring liver fat content

A fat content, liver technology, applied in diagnostic recording/measurement, medical science, diagnostic signal processing, etc., can solve problems such as long inspection time and small measurement area

Inactive Publication Date: 2019-07-02
BEIJING JISHUITAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, considering the long examination time and small measurement area, MRS is not a routine examination method for assessing hepatic steatosis

Method used

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  • Method and device for measuring liver fat content
  • Method and device for measuring liver fat content
  • Method and device for measuring liver fat content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] This embodiment provides a device for measuring liver fat content, comprising a CT scanner, a solid phantom configured on the CT scanner, a quantitative computed tomography QCT module configured on the CT scanner, a QCT workstation, and the quantitative The computed tomography QCT module and the QCT workstation are coupled through signals, and the QCT workstation includes a signal receiving module, an image generating module, an image processing module, and a data output module; the CT scanner configured with a solid phantom performs quantitative computer tomography on the sample Photography QCT scanning, and then the image obtained by CT scanning is transmitted to the signal receiving module of the QCT workstation, and through the image generation module of the QCT workstation, the image processing module converts the Dicom image obtained by CT scanning into a QCT file, and is installed on the workstation The data processing module measures the image and obtains the QCT...

Embodiment 2

[0109] The liver fat percentage results of some sample populations obtained by using the formula formulated by the International Commission on Radiation Units and Measurements (ICRU) recommended standards are negative. The reason may be that there is a small amount of fat tissue in normal liver tissue ( 5-10%). Therefore, this example uses dual-energy (80KV, 120KV) quantitative CT (dual-energy QCT, DEQCT) to determine the equivalent density value of human normal liver tissue on 14 healthy adults, and recalibrates the conversion formula based on this . Two groups of formulas were used to measure QCT liver fat content in the same group of healthy people, and the consistency and correlation between the QCT measurement results and MR mDixon-qaunt measurement results were compared between the two groups.

[0110] 1. Example object

[0111] The subjects of this example come from a sample of people in the Beijing area in a large-scale, multi-center example. The inclusion criteria ...

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Abstract

The invention relates to a method and a device for measuring liver fat content. The method is characterized by comprising the following steps: step 1, performing quantitative computer tomography QCT scanning on a liver sample by using a CT scanner provided with a solid phantom, and transmitting scanned images to a QCT workstation to generate a 3D image after processing; step 2, in a sagittal planeimage, placing three region of interests (ROIs) in the center of the sample, setting detection parameters, and outputting a QCT BMD<Sample>, a slope and a scanning field uniform correction coefficient FUC; and step 3, calculating the fat content of the liver sample.

Description

technical field [0001] The invention relates to a method and device for detecting fat content, in particular to a method and device for measuring liver fat content. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) represents a large group of diseases characterized by fat deposition in the liver and related to metabolic abnormalities such as obesity, diabetes, and hyperlipidemia. The incidence of NAFLD in the general population worldwide is 9-37%, and NAFLD is the most common cause of chronic liver disease in developed countries. Liver biopsy is the gold standard for evaluating NAFLD, but as an invasive test, it is not suitable for disease screening in high-risk populations and efficacy evaluation of NAFLD subjects. In addition, biopsy samples are small in size and there are sampling differences. [0003] Imaging methods currently available for the assessment of hepatic steatosis in NAFLD subjects include ultrasound imaging (US), computed tomography (C...

Claims

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Application Information

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IPC IPC(8): A61B5/00
CPCA61B5/4244A61B5/72
Inventor 过哲徐黎程晓光田伟
Owner BEIJING JISHUITAN HOSPITAL
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