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Traditional Chinese medicine composite preparation for treating angina pectoris made by notoginseng, ixeri sonhifolia extract

A technology for coronary heart disease angina pectoris and composite preparations, which is applied in the field of pharmaceutical preparations for the treatment of coronary heart disease angina pectoris and traditional Chinese medicine composite preparations for the treatment of coronary heart disease angina pectoris, can solve problems such as lack of competitiveness, and achieve non-toxic side effects, high purity, and remarkable curative effect. Effect

Inactive Publication Date: 2009-04-29
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the newly developed Chinese patent medicines in recent years have created a new way for their treatment, they are mainly compound Chinese medicines and lack the competitiveness with international products.

Method used

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  • Traditional Chinese medicine composite preparation for treating angina pectoris made by notoginseng, ixeri sonhifolia extract
  • Traditional Chinese medicine composite preparation for treating angina pectoris made by notoginseng, ixeri sonhifolia extract
  • Traditional Chinese medicine composite preparation for treating angina pectoris made by notoginseng, ixeri sonhifolia extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] 500g of Kudiezi plus 6 times the amount of 70% ethanol for reflux extraction 3 times, 1.5 hours each time, filter, combine the filtrate, recover the ethanol, add water to the medicinal material twice, filter, the filtrate is 1 / 2.28 medicinal material DM130 type macroporous resin (Dry weight) Purification to obtain an extract.

[0133] 500g of Panax notoginseng is appropriately crushed, 250g is added with 4 times the amount of 60% ethanol and refluxed for 3 times, 2 hours each time, filtered, combined the filtrate, recovered the ethanol, add water to the medicinal material twice, stand still for 24 hours, filter, the filtrate is 1 / 3.49 The amount of medicinal material was purified by D101 type macroporous resin (dry weight) to obtain the extract.

[0134] Mix the above two extracts in a uniform ratio: 2:8, add 2 times the amount of polyethylene glycol, heat to melt, and then mix with the remaining Panax notoginseng powder to obtain.

example 2

[0135] Example 2: 800g of Kudiezi plus 6 times the amount of 70% ethanol and reflux extraction 3 times, 1.5 hours each time, filter, combine the filtrate, recover the ethanol, add water to the medicinal material twice, filter, the filtrate is 1 / 2.28 medicinal material type DM130 Purified by macroporous resin (dry weight), the extract was obtained.

[0136] 1000g of Panax notoginseng is appropriately crushed, 500g is added 4 times of 60% ethanol and extracted 3 times, 2 hours each time, filtered, combined the filtrate, recovered ethanol, add water to the medicinal material twice, stand still for 24 hours, filter, the filtrate is 1 / 3.49 The amount of medicinal material was purified by D101 type macroporous resin (dry weight) to obtain the extract.

[0137] Mix the above two extracts in a uniform ratio: 4:6, add 4 times the amount of polyethylene glycol, heat to melt, and then mix with the remaining Panax notoginseng powder to obtain.

example 3

[0138] Example 3: 500g of Kudiezi plus 5 times the amount of 60% ethanol will be left for extraction 2 times, 1 hour each time, filter, combine the filtrate, recover the ethanol, add water to the medicinal material 3 times, filter, the filtrate will be 1 / 2.28 medicinal material amount DM130 type macroporous resin (dry weight) was purified to obtain the extract.

[0139] 1000g of Panax notoginseng was properly crushed, 700 plus 3 times the amount of 70% ethanol was refluxed and extracted 3 times, each 3 hours, filtered, combined the filtrate, recovered the ethanol, added water to twice the medicinal material, stood still for 24 hours, filtered, and the filtrate was 1 / 3.49 The amount of medicinal material was purified by D101 type macroporous resin (dry weight) to obtain the extract.

[0140] Mix the above two extracts in a uniform ratio: 3:7, add 3 times the amount of polyethylene glycol, heat to melt, and then mix with the remaining panax notoginseng powder to obtain

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Abstract

The invention relates to a Chinese medicine complex preparation made from the extract of panax notoginseng and ixeri sonhifolia and used for treating coronary heart disease angina.. Ixeri sonhifolia is added with ethanol for refluxing extraction and then the ethanol is recovered; aquatic D101 type macroporous resin is added for filtration and purification, thus obtaining an extract for standby. The panax notoginseng is crushed, added with part ethanol for refluxing extraction and then the ethanol is recovered; aquatic D101 type macroporous resin is added for purification, thus obtaining an extract for standby; the two extracts are evenly mixed by a ratio, added with polyethylene glycol, heated and molten and then the mixture is evenly mixed with the rest panax notoginseng, thus obtaining the complex preparation. The macroporous resin technique is applied to extracting and separating the panax notoginseng and the ixeri sonhifolia to obtain the extracts of relatively high purity. With compatibility of the panax notoginseng extract and the ixeri sonhifolia extract, the complex preparation has the functions of activating blood, resolving blood stasis, promoting blood circulation and relieving pain as well as significant effect on angina pectoris for coronary heart disease patients, and can also be applied to treating stagnation of the heart-blood and the angina pectoris of coronary heart diseases.

Description

Technical field [0001] The invention relates to a medicinal preparation for treating coronary heart disease and angina pectoris. Specifically, it is a traditional Chinese medicine compound preparation for treating coronary heart disease and angina pectoris made from extracts of Panax notoginseng and Kudiezi, belonging to the technical field of Chinese medicine pharmacy. Background technique [0002] Coronary heart disease is a common middle-aged and elderly disease, and it is currently the main disease causing human deaths. In recent years, authoritative medical and demographic statistics at home and abroad have shown that deaths caused by cardiovascular and cerebrovascular diseases are ranked first among various causes of death. Therefore, the prevention and treatment of atherosclerosis and cardiovascular and cerebrovascular diseases is particularly important. The disease is clinically common and frequently-occurring, and both Chinese and Western medicine have achieved good resu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P9/10
Inventor 隋殿军曲晓波邱智东董金香李银清翁丽丽
Owner CHANGCHUN UNIV OF CHINESE MEDICINE