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A digital imaging system for assays in well plates, gels and blots

An imaging and imaging method technology, applied in the field of assay analysis systems, which can solve problems such as high detector sensitivity

Inactive Publication Date: 2009-04-29
GE HEALTHCARE NIAGARA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This approach yields good sensitivity, but has the following major disadvantages:
[0057] a Requires very high detector sensitivity;

Method used

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  • A digital imaging system for assays in well plates, gels and blots
  • A digital imaging system for assays in well plates, gels and blots
  • A digital imaging system for assays in well plates, gels and blots

Examples

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Embodiment Construction

[0088] Referring now to the drawings, Figure 1 schematically shows a preferred embodiment of an imaging system 1 according to the present invention. System 1 generally includes an illumination system 10 , an imaging subsystem 12 provided within a housing 14 , and a control subsystem 16 . Imaging subsystem 12 includes CCD camera subsystem 18 disposed within camera chamber 20 of housing 14 and lens subassembly 22 extending between camera chamber 20 and sample chamber 24 . In operation, illumination subsystem 10 provides the desired light energy to be imparted on a sample within chamber 24 . Light energy emitted by the sample is transmitted through lens subsystem 22 to camera 18, where an image is formed, and the image is transmitted to control subsystem 16 for processing. The control subsystem 16 includes a camera control unit 26, which is a conventional unit matched to a particular camera 18 and a computer 28 which programs the control unit 26 and receives data from the camera...

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Abstract

An electronic imaging system is disclosed, for assessing the intensity of colorimetric, fluorescent or luminescent signal in a matrix consisting of wells, microwells, hybridization dot blots on membranes, gels, or other specimens. The system includes a very sensitive area CCD detector (18), a fast, telecentric lens (22) with epi-illumination (44), a reflective / transmissive illumination system, an illumination wavelength selection device (34), and a light-tight chamber (24). A computer and image analysis software are used to control the hardware, correct and calibrate the images, and detect and quantify targets within the images.

Description

[0001] This application is a divisional application of an invention patent application with an application date of August 12, 1997, application number 021277478, and the invention title is "Digital Imaging System for Analysis of Well Plates, Gels and Spots". technical field [0002] The present invention relates generally to assay analysis systems, and more particularly to a method for generating randomly arranged samples (eg beads in gels, colonies in petri dishes) or arranged in regular arrays (eg wells in plastic plates, A system and method for a digital image of a sample (spot) disposed on a membrane. The present invention is capable of generating digital images and enabling automated analysis of samples that emit very low fluorescence, chemiluminescence or bioluminescence. In particular, the present invention is designed to analyze the brightness produced by samples in well plates and in gel media, as well as on membranes, on glass, microdevices or other supports. Backg...

Claims

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Application Information

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IPC IPC(8): G01N21/64G02B13/22G02B21/08G02B13/14G02B21/36
CPCG01N21/76G06T2207/30072G01N21/6452G01N21/6456G02B13/14G06T2207/10056G02B13/22G02B21/084G06T7/0046G06T7/75
Inventor 彼得·拉姆孙刚罗尔夫·米勒蒂莫西·奥姆斯比肯尼思·R·卡斯尔
Owner GE HEALTHCARE NIAGARA
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