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Cajanus cajan L. natural medicine with blood sugar reduction and weight reduction function

A natural medicine and hypoglycemic technology, applied in the direction of drug combination, medical preparations containing active ingredients, applications, etc., can solve the problems of small toxic and side effects, multi-target, unstable quality and curative effect, etc., to achieve high safety and application Promising and significant hypoglycemic efficacy

Inactive Publication Date: 2009-05-06
GUANGZHOU YUNZHONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the quality and curative effect of these traditional Chinese medicine preparations may not be stable enough, they all have a common feature of relatively small toxic and side effects and the characteristics of "multi-target" mechanism of action.

Method used

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  • Cajanus cajan L. natural medicine with blood sugar reduction and weight reduction function
  • Cajanus cajan L. natural medicine with blood sugar reduction and weight reduction function
  • Cajanus cajan L. natural medicine with blood sugar reduction and weight reduction function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Extraction and separation of ethanol, methanol, petroleum ether, chloroform and other solvents are domestic analytical reagents; chromatography silica gel is a product of Qingdao Ocean Chemical Factory.

[0038] Take 20 kg of tree bean leaves and extract three times with 95% ethanol under reflux, combine the extracts to recover ethanol under reduced pressure to obtain 1300 g of extract. Take an appropriate amount of extract, stir well in hot water at 60°C, let it settle, and filter. The precipitate was dissolved with methanol, mixed with silica gel, and extracted with petroleum ether and chloroform in turn after removing methanol. The petroleum ether extract, the chloroform extract and the residue were obtained in three parts.

[0039] Put the chloroform extract on the silica gel column, wash the column with 50-50, 30-70, 10-90 petroleum ether-chloroform and 90:10 petroleum ether-acetone in sequence. Take the 50-50 petroleum ether-chloroform eluted part and put it on ...

Embodiment 2

[0041] Compound Structural Identification

[0042] The ultraviolet spectrum was measured with TU-1901 UV-visible spectrophotometer of Beijing General Instrument Company; the infrared spectrum was measured with the American ANALECT RFX65A spectrometer; the mass spectrum was measured with the QP5000 mass spectrometer or the American API2000LC / MS / MS system; the nuclear magnetic resonance spectrum was measured with the German- The DRX-400 400M superconducting nuclear magnetic resonance instrument of the Swiss Bruker Company was used for the measurement, and TMS was used as the internal standard.

[0043] For structural formula see attached figure 1 , 13 C NMR data are shown in Table 1.

[0044] Compound 1: C 20 h 22 o 2 ;White needle crystal, easily soluble in chloroform, slightly soluble in methanol; and FeCl 3 The reaction was yellow. The mass spectrum gives the molecular ion peak of m / z 294, combined with the 20 carbon signals of the carbon spectrum and the 22 proton si...

Embodiment 3

[0062] Hypoglycemic effect of a natural plant-derived scorpion compound composition

[0063] Drug to be tested for activity: the chloroform fraction of the methanolic extract of the tree bean leaf.

[0064] Chemical composition characteristics: As mentioned above, the chloroform part contains three newly discovered stilbene compounds cajanolactone A (cajanolactone A, 3), cajanonic acid A (Cajanonic acid A, 4) and cajanolactone B (cajanolactone B, 5); and known stilbene compounds longistylin C (1), Longstylin A (2). It is called the jacaronic acid A composition.

[0065] Pharmacological experiment method: Determination of fasting blood glucose: Blood was collected after the animals were fasted for 4 hours (from 9:00 in the morning) on ​​the 0th day (no drug administration), the 5th day and the 12th day (the last day of drug administration). Blood was obtained from the tail vein. Blood glucose was measured at 1.00pm in the afternoon with a glucose analyzer (Hemocue AB, Angelh...

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Abstract

The invention discloses a natural medicament with the functions of hyperglycemic and lipid lowering as well as weight losing. The medicament is a resveratrol compound pigeon bean acid ketone A which can be prepared into a medicament preparation for curing diabetes or adiposity, and can also be prepared into a health-care food which is beneficial to a diabetes suffer or an adiposity suffer. The invention simultaneously discloses a compound of a plant source containing the pigeon bean acid ketone A as well as the use of the medicament and the health-care food thereof used for curing the diabetes.

Description

technical field [0001] The present invention relates to a kind of natural medicine japonica acid A with a new chemical structure, which can be used to produce blood sugar-lowering and lipid-lowering weight-loss medicine or health food; The composition of A can produce hypoglycemic drugs or health food. Background technique [0002] Diabetes mellitus is a syndrome caused by insufficient insulin secretion and (or) insulin resistance, with hyperglycemia as the main manifestation and involving metabolic disorders of various substances. With the change of people's lifestyle, the prevalence of diabetes is on the rise. Epidemiological surveys show that diabetes is highly prevalent in developing countries. In 2005, there were 220 million people suffering from diabetes in the world, including 40 million patients in my country. Many more people are also at risk for reduced glucose tolerance. About 90% have type 2 diabetes. The onset of diabetes is slow, the symptoms are hidden, and...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P3/10A61P3/06
CPCA23V2002/00A23L1/3002A61K31/192A23L33/105A61K36/48
Inventor 邱声祥沈小玲
Owner GUANGZHOU YUNZHONG BIOTECH
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