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Bear gall soft capsules and preparation method thereof

A soft capsule and bear bile technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, can solve the problems of slow onset of action, easy absorption of moisture by bear bile powder, affecting curative effect, etc., and achieves a remarkable effect. Effect

Inactive Publication Date: 2009-05-06
天津白头山制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because it has a fishy smell, it is easy to feel nauseated after taking it, and because of its bitter and cold taste, some pharmaceutical companies put it into capsules to remove the above adverse reactions
However, the capsule preparations of bear bile powder on the market are all bear bile powder hard capsules. Bear bile powder is mixed with other auxiliary materials and packed into hard capsules. Bear bile powder is very easy to absorb moisture and is difficult to preserve. Agglomeration will affect the curative effect, and there is a process of dissolving and absorbing the solid substance into the stomach, and the onset of effect is slow

Method used

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  • Bear gall soft capsules and preparation method thereof
  • Bear gall soft capsules and preparation method thereof

Examples

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Effect test

Embodiment 1

[0066] Embodiment 1: a kind of bear bile soft capsule is characterized in that comprising bear bile powder, matrix and capsule shell, wherein the weight share ratio of bear bile powder and matrix is ​​bear bile powder 1.5, matrix 15.0; Substrate comprises Polyethylene Glycol 4005.0 , propylene glycol 5.0, glycerin 5.0; the capsule shell includes gelatin, pure water, glycerin and polyethylene glycol 400, and its weight share ratio is gelatin 50.0, pure water 50.0, glycerin 15.0, polyethylene glycol 400 1.1.

[0067] The preparation method of above-mentioned Xiongdan soft capsule is characterized in that comprising the following steps:

[0068] (1) Preparation of the core of Xiongdan Soft Capsules: Weigh an appropriate amount of matrix according to the above ratio, add it to a container with stirring, heat up to 35°C under stirring, slowly add bear bile powder to dissolve it, and wait until it is completely dissolved , stop stirring, and leave standstill at 34°C to make bear bil...

Embodiment 2

[0071] Embodiment 2: a kind of bear bile soft capsule is characterized in that comprising bear bile powder, matrix and capsule shell, and wherein the weight share ratio of bear bile powder and matrix is ​​bear bile powder 2.0, matrix 1.0; Substrate comprises Polyethylene Glycol 400 0.1, polyethylene glycol 800 0.03, propylene glycol 0.47, glycerin 0.3, methyl sorbate 0.05, methyl cellulose 0.05; capsule shell includes gelatin, pure water, glycerin, polyethylene glycol 400, polyethylene glycol 600, and The weight share ratio is 40.0 for gelatin, 60.0 for pure water, 5.0 for glycerin, 0.04 for polyethylene glycol 400, and 0.06 for polyethylene glycol 600.

[0072] The preparation method of above-mentioned Xiongdan soft capsule is characterized in that comprising the following steps:

[0073] (1) Preparation of the core of Xiongdan Soft Capsules: Weigh an appropriate amount of matrix according to the above ratio, add it to a container with stirring, heat up to 37°C under stirring...

Embodiment 3

[0076] Embodiment 3: a kind of bear bile soft capsule is characterized in that comprising bear bile powder, matrix and capsule shell, and wherein the weight share ratio of bear bile powder and matrix is ​​bear bile powder 1, matrix 30; Substrate comprises Polyethylene Glycol 200 4.0, macrogol 400 2.0, macrogol 600 1.5, macrogol 800 0.5, macrogol 1500 0.6, macrogol 4000 0.3 and macrogol 60000.1, propylene glycol 3.0, glycerin 5.0, peanut oil 1.0, soybean oil 1.0, corn oil 1.0, mineral oil 1.0, blended oil 1.2, sorbic acid 0.1, methyl sorbate 0.3, methyl p-hydroxybenzoate 0.2, ethyl p-hydroxybenzoate 0.2, propyl p-hydroxybenzoate 0.1 , Butyl p-hydroxybenzoate 0.3, Benzoic acid 0.4, Sodium sulfite 1.2, Sodium metabisulfite 0.4, Sodium thiosulfate 0.6, Pyrogallic acid 0.3, Thiourea 0.7, α-tocopherol 0.5, Ascorbic acid 0.5, Beeswax 0.5, Methyl Cellulose 0.5, ethyl cellulose 0.5 and hydroxypropyl methyl cellulose 0.5; capsule shell includes gelatin, purified water, glycerin and poly...

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Abstract

The invention aims at providing a bear bile soft capsule and a preparation method thereof. The bear bile soft capsule consists essentially of bear bile powder, a substrate and a capsule shell. The preparation method is as follows: the bear bile powder is highly uniformly dispersed into the solvent of the substrate according to proportion and prepared into the soft capsule. The soft capsule has the advantages of quick absorption of effective components, high bioavailability and good seal performance of a capsule core, thus avoiding the original fishy smell of the product and ensuring the stability of the effective components; and the preparation method thereof is stable in technical conditions and suitable for scale industrial production.

Description

(1) Technical field: [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a bear bile soft capsule and a preparation method thereof. (two) background technology: [0002] Bear bile powder has the effects of clearing away heat, calming the liver, and improving eyesight. It is mostly used for convulsions, convulsions, and sore throat. However, because it has a fishy smell, it is easy to feel nauseated after taking it, and because of its bitter and cold taste, some pharmaceutical companies put it into capsules to remove the above-mentioned adverse reactions. However, the capsule preparations of bear bile powder on the market are all bear bile powder hard capsules. Bear bile powder is mixed with other auxiliary materials and packed into hard capsules. Bear bile powder is very easy to absorb moisture and is difficult to preserve. Agglomeration will affect the curative effect, and the solid substance takes a process of dissolution and ...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/48A61K47/34A61K47/42A61K47/44A61P11/04A61P43/00A61K47/10
Inventor 金吉山
Owner 天津白头山制药有限公司
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