Diaryl benzo pyridine derivative, and preparation and use thereof
A technology of benzopyrimidine and diaryl, which is applied in the application and preparation field of related drugs, and achieves the effects of low cytotoxicity, novel structure and simple preparation method
Inactive Publication Date: 2009-06-24
FUDAN UNIV
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The invention belongs to the medicine technical field, and provides a series of diaryl benzo pyrimidine derivatives (DABPs) of formula I, pharmaceutical salt thereof, stereochemical isomers thereof, a hydrate and a solvolyte thereof, a polycrystal and an eutectic crystal thereof, a precursor and a derivative thereof with the same biological function, a preparation method thereof and application of a composition containing one or a plurality of the compounds to related medicines for treating AIDS and the like. The results of pharmacological experiments prove that the compounds have obvious anti-HIV-1 virus activity, can effectively inhibit replication of MT-4 cells infected by the HIV-1 virus, and have low cytotoxicity.
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