Pharmaceutical composition for treating inflammation of gynecology
A technology for gynecological inflammation and a composition is applied in the field of pharmaceutical compositions for treating gynecological inflammation, and can solve the problems of being infected by exogenous bacteria due to insufficient disinfection, delaying the disease condition, and unsatisfactory curative effect.
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Embodiment 1
[0030] Writhing Pain Response Induced by Glacial Acetic Acid in Mice
[0031] Experimental medicine: pharmaceutical composition of the present invention; King Kong rattan syrup (purchased by Beijing Baitasi Pharmaceutical Wholesale Company, produced by Zhonglian Pharmaceutical Factory in Wuhan); Glacial acetic acid (produced by Beijing Chemical Plant)
[0032] Experimental method: ICR mice, 20 ± 5 grams, administered once every morning and afternoon (oral drug administration or mouse tail vein administration), intraperitoneal injection of 0.7% ice Acetic acid, observe the number of mouse pains caused by pain in mice within 5 minutes, see Table 2
[0033] Table 2 Comparison of writhing times in mice
[0034]
[0035] Note: Compared with the control group ** P<0.01, compared with the positive control group #P<0.05.
Embodiment 2
[0037] In vivo antibacterial experiment
[0038] Experimental medicine: pharmaceutical composition of the present invention; King Kong rattan syrup (purchased by Beijing Baitasi Medicine Wholesale Company, produced by Zhonglian Pharmaceutical Factory in Wuhan);
[0039] Experimental method: ICR mice, 20 ± 5 grams, infected mice with 3000 / ml Proteus intraperitoneal administration, after 6 hours of infection, administration (oral drug administration by gavage, injection drug administration by tail vein of mice) , observe the death rate of mice, see Table 3:
[0040] Table 3 Mortality of mice
[0041]
[0042] Note: Compared with the control group ** P<0.01, compared with the positive control group #P<0.05.
[0043] Conclusion: Pharmacological experiments show that the smilax saponins pharmaceutical composition of the present invention has good pharmacological effects, and we can know that each group of preparations of the present invention has stronger pharmacological effe...
Embodiment 3
[0058] Take King Kongteng decoction pieces, add water to extract, filter the extract, concentrate, add ethanol to the concentrate, let stand, put the supernatant on a macroporous adsorption resin column, the macroporous adsorption resin is NKA, first elute with water, discard the eluent, Then elute with 75% ethanol, combine the eluents, recover the ethanol to the maximum, add an organic solvent for extraction, the organic solvent is acetone, keep the organic phase, recover the organic solvent to the maximum, and dry to obtain smilax saponin.
[0059] The soft capsule contains 6.2 grams of smilax saponin, 6.2 grams of soybean oil as a medicinal excipient; It is 5.8 grams, and the medicinal auxiliary material sodium chloride is 5.8 grams; the large infusion smilax saponin is 5.8 grams, and the medicinal auxiliary glucose is 5.8 grams; the powder injection is 5.8 grams, and the medicinal auxiliary mannitol is 5.8 grams; 5.8 grams of smilax saponin for freeze-dried powder injectio...
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