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Pharmaceutical composition for treating inflammation of gynecology

A technology for gynecological inflammation and a composition is applied in the field of pharmaceutical compositions for treating gynecological inflammation, and can solve the problems of being infected by exogenous bacteria due to insufficient disinfection, delaying the disease condition, and unsatisfactory curative effect.

Inactive Publication Date: 2009-07-01
北京卓越同舟药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Including female vulvitis, vaginitis, cervicitis, and pelvic inflammatory disease caused by various reasons. The pain caused by gynecological inflammation includes middle and lower abdominal pain, low back pain, menstrual disorders, itching, dysmenorrhea, excessive leucorrhea, dyspareunia, etc. Gynecological inflammation is a common disease and prone to occur in women. Gynecological inflammation is not only caused by endogenous bacterial infection in women's physical decline such as childbirth, artificial abortion, medical abortion, menstruation, fatigue, and surgery, but also because of unclean female products, Unhygienic menstruation, unclean sex life, and lax disinfection during surgery are caused by exogenous germ infection, which has seriously affected women's physical and mental health for a long time. Many patients are ashamed to seek medical treatment or have no time to go to the hospital for treatment. The disease is delayed, resulting in serious consequences. And all kinds of gynecologically proven treatments have been inseparable from drugs for many years. Some physiotherapy treatments are used in the chronic phase, but the curative effect is mostly unsatisfactory. And the recurrence rate is quite high The incidence rate of gynecological diseases in China is 50% (some remote mountainous areas, due to backward sanitation and prevention level, the incidence rate is as high as 100%), especially more than 85% of married women suffer from various gynecological diseases to varying degrees
[0004] At present, there are two main methods for the clinical treatment of gynecological inflammation. One is the treatment of western medicine antibiotics. Although this method can relieve some clinical symptoms, some reasons such as the easy recurrence of gynecological inflammation and antibiotic resistance lead to the treatment of antibiotics. The other is the application of traditional Chinese medicine lotion, which is very difficult for patients to use in the course of treatment, and because most of the traditional Chinese medicine lotion has a strong smell of medicine, it has a huge negative impact on patients, resulting in patients taking medication poor compliance
[0005] Now on the market, the clinical preparation of King Kongteng is syrup. The disadvantage of syrup is that it takes a large volume, and the patient has a bad taste, and it is not easy to carry and store; the patent application number is 03114644 "a kind of King Kongteng granule for treating gynecological inflammatory diseases and its preparation method” patent describes the preparation of granules with King Kongteng as a raw material. The King Kongteng granules obtained in this patent invention have a large dosage, are inconvenient to take, and have a poor taste, and the applied methods are relatively traditional methods. , poorer in terms of patent innovation

Method used

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  • Pharmaceutical composition for treating inflammation of gynecology
  • Pharmaceutical composition for treating inflammation of gynecology
  • Pharmaceutical composition for treating inflammation of gynecology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Writhing Pain Response Induced by Glacial Acetic Acid in Mice

[0031] Experimental medicine: pharmaceutical composition of the present invention; King Kong rattan syrup (purchased by Beijing Baitasi Pharmaceutical Wholesale Company, produced by Zhonglian Pharmaceutical Factory in Wuhan); Glacial acetic acid (produced by Beijing Chemical Plant)

[0032] Experimental method: ICR mice, 20 ± 5 grams, administered once every morning and afternoon (oral drug administration or mouse tail vein administration), intraperitoneal injection of 0.7% ice Acetic acid, observe the number of mouse pains caused by pain in mice within 5 minutes, see Table 2

[0033] Table 2 Comparison of writhing times in mice

[0034]

[0035] Note: Compared with the control group ** P<0.01, compared with the positive control group #P<0.05.

Embodiment 2

[0037] In vivo antibacterial experiment

[0038] Experimental medicine: pharmaceutical composition of the present invention; King Kong rattan syrup (purchased by Beijing Baitasi Medicine Wholesale Company, produced by Zhonglian Pharmaceutical Factory in Wuhan);

[0039] Experimental method: ICR mice, 20 ± 5 grams, infected mice with 3000 / ml Proteus intraperitoneal administration, after 6 hours of infection, administration (oral drug administration by gavage, injection drug administration by tail vein of mice) , observe the death rate of mice, see Table 3:

[0040] Table 3 Mortality of mice

[0041]

[0042] Note: Compared with the control group ** P<0.01, compared with the positive control group #P<0.05.

[0043] Conclusion: Pharmacological experiments show that the smilax saponins pharmaceutical composition of the present invention has good pharmacological effects, and we can know that each group of preparations of the present invention has stronger pharmacological effe...

Embodiment 3

[0058] Take King Kongteng decoction pieces, add water to extract, filter the extract, concentrate, add ethanol to the concentrate, let stand, put the supernatant on a macroporous adsorption resin column, the macroporous adsorption resin is NKA, first elute with water, discard the eluent, Then elute with 75% ethanol, combine the eluents, recover the ethanol to the maximum, add an organic solvent for extraction, the organic solvent is acetone, keep the organic phase, recover the organic solvent to the maximum, and dry to obtain smilax saponin.

[0059] The soft capsule contains 6.2 grams of smilax saponin, 6.2 grams of soybean oil as a medicinal excipient; It is 5.8 grams, and the medicinal auxiliary material sodium chloride is 5.8 grams; the large infusion smilax saponin is 5.8 grams, and the medicinal auxiliary glucose is 5.8 grams; the powder injection is 5.8 grams, and the medicinal auxiliary mannitol is 5.8 grams; 5.8 grams of smilax saponin for freeze-dried powder injectio...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating gynecological inflammation and preparation method thereof, composed of effective components extracted by the China smilax root and pharmaceutical adjuvant. Various pharmaceutical acceptable preparations for treating gynecological inflammation, such as solid preparation, injection preparation are prepared by mixing the effective components extracted by the China smilax root and pharmaceutical adjuvant. The pharmacological experiment result of the traditional Chinese medicine preparation shows that: the traditional Chinese medicine preparation has good curative effect on treating gynecological inflammation, with better pharmacological effects compared with the commercial drugs.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical composition for treating gynecological inflammation. Background technique [0002] King Kong rattan medicine name Smilax, also known as King Kong thorn, belongs to Liliaceae plant, sweet, warm, non-toxic, can dispel rheumatism, diuresis, detumescence poison, clinically can be used to treat surgical acute infection, rheumatoid arthritis, cancer swelling etc. [0003] Gynecological inflammation mainly refers to the inflammation of women's reproductive organs. Including female vulvitis, vaginitis, cervicitis, and pelvic inflammatory disease caused by various reasons. The pain caused by gynecological inflammation includes middle and lower abdominal pain, low back pain, menstrual disorders, itching, dysmenorrhea, excessive leucorrhea, dyspareunia, etc. Gynecological inflammation is a common disease and prone to occur in women. Gynecol...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/14A61K9/20A61K9/48A61K47/02A61K47/10A61K47/26A61K47/34A61K47/22A61K47/44A61P15/00
Inventor 王爱民李伟郝志栋
Owner 北京卓越同舟药物研究院有限公司
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