Oncolytic adenoviruses for the treatment of cancer

An oncolytic adenovirus, adenovirus technology, applied in the field of tumor biology, can solve problems such as lack of potency, genome instability, and interference with promoter virus sequences
CN101484583AInactive Publication Date: 2009-07-15DNATRIX
0 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DNATRIX
Publication Date
2009-07-15
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human DNA sequence isolating a promoter conferring selective expression on an adenoviral gene. Said adenovirus can also contain a sequence that optimises the protein translation of an adenoviral gene regulated by a promoter conferring tumour selectivity. The invention is suitable for use in the treatment of cancer.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The field of the invention relates primarily to the field of tumor biology. In particular, the present invention relates to adenoviruses that replicate selectively in tumors (called oncolytic adenoviruses) and their use for inhibiting cancer. Background technique

[0002] Existing treatments for cancer are mainly based on chemotherapy, radiation therapy and surgery. Although early stage cancers have a high cure rate, most cases of advanced stage cancers are incurable because they cannot be removed surgically or because their doses are limited due to the toxicity of radiation therapy or chemotherapy to normal cells . To alleviate this situation, biotechnologies have been developed that seek to improve the efficacy and selectivity of cancer treatments. Among them, gene therapy and virotherapy use viruses to treat cancer. In gene therapy, viruses are modified to prevent their replication and to serve as vehicles or carriers of therapeutic genetic mate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More