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Nano-level traditional Chinese medicine preparation for livestock and bird

A nano-scale, granular preparation technology, applied in the field of veterinary medicine, can solve the problems of organic solvent residues, affecting the efficacy of drugs, and low efficiency of ball mills, and achieve the effects of increasing stability, improving bioavailability, and saving manpower and material resources

Active Publication Date: 2012-06-06
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is not limited by the solubility of traditional Chinese medicine, and can be applied to the preparation of insoluble traditional Chinese medicine such as pearl powder, but the disadvantages of this method are time-consuming, high noise and low production volume
The efficiency of the ball mill is low, and one operation sometimes takes several days, and the diameter, quantity and type of the balls need to be different according to the type of traditional Chinese medicine to be ground.
CN 200410031357.2 discloses a method for preparing nano-preparation of traditional Chinese medicine, which includes pretreatment, preparation of suspension, pulverization and filtration, and nanometerization steps. However, the step of preparing suspension cannot completely extract the medicinal components of traditional Chinese medicine, which affects the efficacy of the medicine. Curative effect; at the same time, a large amount of organic solvents are used in the extraction process, which may easily cause the residue of organic solvents in the medicinal materials, thereby affecting the preparation of subsequent dosage forms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Pulsatillae nanoparticle preparation: remove impurities from Pulsatillae medicinal material, wash, cut into sections, then grind, pass through a 60-mesh sieve, and set aside; first extract the treated medicinal material: extract with 8 times the amount of water of the medicinal material, extract The temperature is 95±3°C, adjust the pH to 2-5 with 10% hydrochloric acid for the first extraction, and decoct for 2 hours; add water to 8 times the weight of the medicinal material for the second extraction, and adjust with 15% sodium hydroxide The pH is 8-9, the extraction time is 1.5 hours, and the obtained medicinal liquid is collected for later use; the obtained medicinal liquid is ultrasonically crushed to make the medicinal material particles in it smaller than 10 μm, and the suspension is filtered to obtain the filtrate; the obtained filtrate is collided with a nanoscale machine pulverization, so that the particle size of the medicinal material therein rea...

Embodiment 2

[0028] Preparation of Bupleurum nano-scale preparation: remove impurities from the Bupleurum medicinal material, wash, cut into sections, then grind, pass through a 60-mesh sieve, and set aside; first extract the processed medicinal material: extract with 8 times the amount of medicinal material in water, The extraction temperature is 95±3°C. For the first extraction, use 15% acetic acid to adjust the pH to 2-5, and decoct for 2 hours; for the second extraction, add water to 8 times the weight of the medicinal material, and use 10% sodium bicarbonate Adjust the pH to 8-9, the extraction time is 1.5 hours, collect the obtained medicinal liquid for later use; ultrasonically pulverize the obtained medicinal liquid to make the medicinal material particles in it smaller than 10 μm, filter the suspension to obtain the filtrate; crushing by colliding machine, so that the particle size of the medicinal material therein reaches the size of 50-500nm, to obtain the nanometer traditional C...

Embodiment 3

[0030] Preparation of motherwort nano-scale preparations: remove impurities from the motherwort medicinal material, wash, cut into sections, then grind, pass through a 60-mesh sieve, and set aside; first extract the treated medicinal material: extract with 8 times the amount of water of the medicinal material, and the extraction temperature 95±3°C, adjust the pH to 2-5 with 12% phosphoric acid for the first extraction, and decoct for 2 hours; still add water to 8 times the weight of the medicinal material for the second extraction, and adjust the pH to 2-5 with 18% sodium carbonate 8-9, the extraction time is 1.5 hours, and the obtained medicinal liquid is collected for later use; the obtained medicinal liquid is ultrasonically pulverized so that the medicinal material particles in it are smaller than 10 μm, and the suspension is filtered to obtain a filtrate; the obtained filtrate is pulverized with a nano-scale collider , so that the particle size of the medicinal materials t...

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Abstract

The invention relates to a nanometer traditional Chinese medicine preparation for beasts and birds, and a preparation method thereof. The preparation comprises suspensions, granules, capsules, injections, premix and other preparation formulations.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a nanoscale traditional Chinese medicine preparation for livestock and poultry. Background technique [0002] A nanometer is a unit of length in physics, and a nanometer is one-billionth of a meter. When the particle size range is between 0.1-100nm, it is in the transition zone between the atomic cluster and the macroscopic object, with quantum size effect, small size effect, surface effect and macroscopic quantum tunneling effect, etc., in the acoustic, magnetic, optical, electrical Compared with the bulk material, the properties such as heat and heat are significantly different. For example, at room temperature, 3nm Ag particles have metal characteristics, and when the particle size is further reduced or the temperature is lowered, the Ag particles will exhibit non-metal characteristics. Nanotechnology group is a high-tech discipline that manipulates a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00A61K36/71A61K36/533A61K36/233A61K9/10A61K9/14A61K9/16A61K9/50
Inventor 李旭东刘菁苏建东
Owner TIANJIN RINGPU BIO TECH
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