Electronic biosensor arrangement

Abstract

Electronic biosensor arrangement (1) comprising a receptacle region (2) for biological material, to which is assigned a sensor electrode arrangement (3) with sensor electrodes (3a, 3b) intermeshing in comblike fashion, to which can be connected a measuring circuit (5) for measuring an electrical measurement quantity influenced by biological material at the sensor electrodes (3a, 3b), wherein the sensor electrodes (3a, 3b) form a multiplicity of sensor capacitors (Csensor,1 to Csensor,N) which are assigned electronic switching means (S2,1 to S2,N) - driven by a control logic (8) - for connection to earth or to a voltage source carrying a measurement voltage (Vdrive), comprising a reference capacitor (Cref), which is likewise assigned a switching means (S1) - driven by the control logic (8) - for optional connection to earth or to the measurement voltage (Vdrive), wherein the capacitors (Cref, Csensor,1 - Csensor,N) are on the other hand combined at a node (A), which is connected to an input (-) of a differential amplifier (10) and to which are furthermore connected measuring capacitors (C0 to C5) having binary weighted capacitances (Cmin to 32Cmin) for forming an SAR comparison unit, which, on the other hand, via switching means (S3,0 to S3,5) driven by the control logic (8), are able to be connected selectively to a voltage source (Varray) or to earth for the purpose of charge difference formation for the SAR conversion.

Description

technical field [0001] The invention relates to an electronic biosensor device with a receiving area for biological material corresponding to a sensing electrode arrangement with comb-shaped intermeshing sensing electrodes (Sensorelektroden), wherein for measuring A measurement circuit for an electrical measurement parameter influenced by the biological material can be connected to the sensing electrode arrangement. Background technique [0002] Such a biosensor device is disclosed, for example, by E. Laureyn et al., "Nanoscaled interdigitated titanium electrodes for impedimetric biosensing", Sensors and Actuators B, Vol. 68 (2000), pages 360-370. In this literature, efforts are made to detect affinity-based interactions between complementary molecules, where the binding of a target molecule to a selective detection layer induces electrical properties in the region of comb-like intermeshing electrodes. This change can be detected as an impedance shift, whereby a direct elec...

AI Technical Summary

Problems solved by technology

Therefore, it is more troublesome to monitor this biological reaction process by using known biosensor devices, and if many such reaction processes are to be monitored, the cost of the instrument is also very high

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