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Electrochemical 18F extraction, concentration and reformulation method for radiolabeling

A technology for electrochemical components and extraction electrodes, applied in the application of radioactive source radiation, devices for transforming chemical elements by radiation, radioactive sources, etc., can solve the problems of inability to concentrate radioactive isotopes

Inactive Publication Date: 2009-08-19
TRASIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, standard ion-exchange resin techniques cannot concentrate radioisotopes in volumes below about 100 microliters, which must be progressed from the initial milliliter-scale solution of [18F]fluoride to the microliters required for this synthesis.

Method used

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  • Electrochemical 18F extraction, concentration and reformulation method for radiolabeling
  • Electrochemical 18F extraction, concentration and reformulation method for radiolabeling
  • Electrochemical 18F extraction, concentration and reformulation method for radiolabeling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Example 1: EDLE of [18F] fluoride ions on carbon fibers

[0052] in such as figure 1 In the electrochemical device shown in , the large specific surface area conductive material 7 is composed of carbon fiber bundles. The specific surface area in this case was 4375 cm 2 / g. A voltage of +3V is applied to electrode 4, which polarizes the carbon fiber bundle. 2 ml of a solution containing 1.47 mCi [18F] obtained by rinsing the cyclotron target with water and diluting it was passed through the electrochemical cell within 1 min using a syringe pump. The emissions extracted from this solution and actually trapped in the electrochemical cell are measured. This was able to extract 98+% (1.44mCi) of the radiation entering the element.

Embodiment 2

Embodiment 2: [18F] fluoride ions in network glassy carbon ( , from EDLE on ERG, Oakland, Canada)

[0053] in such as figure 1 In the electrochemical device shown in , the large surface area conductive material 7 is in this case carbon aerogel / nanofoam. A voltage of +6V was applied to electrode 4, which polarized the network glassy carbon. 2 ml of a solution containing 1.4 mCi [18F] as obtained in Example 1 was passed through the electrochemical cell within 1 minute using a syringe pump. The radioactivity extracted from this solution and actually trapped in the electrochemical element is measured. It was able to extract 31+% (405 μCi) of the activity going into the element.

Embodiment 3

Example 3: EDLE of [18F]fluoride on carbon aerogel / nanofoam monolith (from Marketech International Inc., Port Townsend, WA, USA)

[0054] in such as figure 1 In the electrochemical device shown in , the large surface area conductive material 7 is in this case carbon aerogel / nanofoam. A voltage of +3V was applied to electrode 4, which polarized the carbon airgel / nanofoam. 2 ml of a solution containing 1 mCi[18F] as obtained in Example 1 was passed through the electrochemical cell within 1 minute using a syringe pump. The radioactivity extracted from this solution and actually trapped in the electrochemical element is measured. It was able to extract 19+% (194 μCi) of the activity going into the element. In fact, there are preferential pathways near carbon aerogels. Furthermore, the liquid could not enter the nanopores due to the short transit time; if the flow rate was reduced by a factor of four, the extraction of radioactivity was 36%.

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Abstract

The present invention relates to a method to extract out of water, concentrate and reformulate [18F] fluorides, said method comprising the successive steps of : - passing a dilute aqueous [18F] fluoride solution entering by an inlet (1) in a cavity (6) embodying an electrochemical cell with at least two electrodes (3, 4, 5), flowing in the cavity (6) and coming out of the cavity (6) by an outlet (2), an external voltage being applied to said electrodes, one electrode (4) being used as an extraction electrode, another one (3) being used for polarizing the solution, and configured so that at least the extraction electrode (4), either used as a cathode or as an anode, is in contact with and polarizes a large specific surface area conducting material (7), contained in the cavity (6); - releasing the extracted ions from the surface of the large specific surface area conducting material (7) by turning off the applied external voltage, wherein, during its passage in the cavity (6), the dilute aqueous [18F] fluoride solution entirely crosses and internally soaks the large specific surface area conducting material (7).

Description

technical field [0001] The present invention relates to an electrochemical method for the extraction, concentration and reformation of [18F]fluoride contained in water. The [18F]fluoride ion is usually obtained by irradiating the H with protons 2 18 O (i.e. enriched water) to produce. In a further step, the [18F] radioactive ion can be transferred into an organic medium suitable for nucleophilic substitution, which is usually the first step in radiotracer synthesis. Background technique [0002] Positron emission tomography (PET) is an imaging method for obtaining quantitative molecular and biochemical information about physiological processes in vivo in humans. The most common PET radiotracer in use today is [18F]-fluorodeoxyglucose ([18F]-FDG), a radiolabeled glucose molecule. PET imaging using [18F]-FDG enables visualization of glucose metabolism and has a wide range of clinical indications. Among positron emitters including [11C] (20 min half-life), [150] (2 min), [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G21G4/00
CPCG21G4/08G21H5/02G21G2001/0015
Inventor J-L·莫雷勒S·沃齐亚G·菲利帕特
Owner TRASIS