Oral pharmaceutical preparation of dioscorea panthaica total sapogenin and preparation method and application thereof

A technology of total saponins and saponins, which is applied in the direction of drug combinations, pharmaceutical formulas, antipyretics, etc., can solve the problems of blank effects and application conditions, neglect of total saponins of yellow yam, etc., to improve bioavailability and prolong residence time , the effect of promoting absorption and utilization

Inactive Publication Date: 2009-09-16
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technologies have neglected the research on the total saponins of Huangyam yam, and its effects and applications have always been in a blank state.

Method used

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  • Oral pharmaceutical preparation of dioscorea panthaica total sapogenin and preparation method and application thereof
  • Oral pharmaceutical preparation of dioscorea panthaica total sapogenin and preparation method and application thereof
  • Oral pharmaceutical preparation of dioscorea panthaica total sapogenin and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Take 100g of total saponins of Huangyam yam, add 20g of chitosan, 10g of carbomer, 50g of poloxamer, 50g of lecithin, 30g of micronized silica gel, 80g of beta cyclodextrin, and add starch to 450g. Crushed and mixed for 30 minutes, granulated, dried, granulated, and made into capsules.

Embodiment 2

[0144] Get 80g of total saponins of Chinese yam and 10g of total saponins of Dioscorea baicalensis, add chitosan 20g, poloxamer 30g, lecithin 10g, micropowder silica gel 30g, beta cyclodextrin 20g, microcrystalline cellulose 50g, and Add starch to 300g, vibrate mill for ultrafine pulverization for 30 minutes, add 70% ethanol to combine for 10 minutes, make pellets, granulate and round, dry, polish, and make pills.

Embodiment 3

[0146] Take 120g of total saponins of Huangyam yam, add 2g of chitosan, 10g of lecithin, 1g of aspartame, and add dextrin to 200g, stir evenly, dry press granules, and pack separately to make granules.

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Abstract

The invention discloses an oral pharmaceutical preparation of dioscorea panthaica total sapogenin and a preparation method and application thereof, pertaining to the field of traditional Chinese medicine. In respect of the pharmaceutical preparation, the sapogenin obtained by hydrolyzation of sapogenin compositions in dioscorea panthaica is matched with high-efficiency medical auxiliary materials and mixed evenly by the method of micronization, and then the oral pharmaceutical preparation is produced. The pharmaceutical preparation can enhance the dispersibility, wettability and solubility of the sapogenin compositions, increase the absorption and utilization degree of the sapogenin and improve the biological utilization degree of the sapogenin, and has outstanding effects in treating diseases such as gout disease, hyperlipemia, diabetes, coronary heart disease, angina, rheumatism, depressive illness and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing total saponins of yam yam, in particular to an oral pharmaceutical preparation in which saponins in yam yam are hydrolyzed into main active ingredients and uses thereof. It belongs to the field of traditional Chinese medicine. Background technique [0002] Yellow yam Dioscorea panthaica Prain et Burkill is a plant of the genus Dioscorea, mainly distributed in Yunnan, Guizhou, Sichuan, Hunan and other regions. The root contains 1.7-2.3% diosgenin. The crude drug can dispel wind and dampness, clear away heat and detoxify, and can treat stomach problems, Rheumatic heart disease, rheumatoid arthritis, bruises, anthrax of cattle and horses. Yellow yam mainly contains saponins, steroidal saponins such as diosgenin, pseudoprotodiosgenin, and slender saponin. Diosgenin (diosgenin, Dio) is one of the steroidal saponins, also known as diosgenin or diosgenin. Dioscin, which is the product of diosc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61K9/48A61K9/16A61K47/38A61K47/32A61K47/40A61K47/34A61K47/24A61K47/10A61P9/10A61P29/00A61P19/06A61P3/06A61P3/10A61K125/00A61K47/04A61K47/36
Inventor 周小明刘国飞
Owner 北京凯瑞创新医药科技有限公司
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