Atap peptides, nucleic acids encoding the same and associated methods of use

A nucleic acid and polynucleotide technology, applied in apoptosis-related proteins, chemical instruments and methods, medical preparations containing active ingredients, etc., can solve problems such as unpleasantness and high toxicity in cancer patients
CN101557818AInactive Publication Date: 2009-10-14RUTGERS THE STATE UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
RUTGERS THE STATE UNIV
Publication Date
2009-10-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed herein are nucleic acid sequences that encode pro-apoptotic polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of proliferative disorders and bacterial infections using the nucleic acids and proteins of the invention.
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Description

[0001] References to related applications

[0002] Pursuant to 35 U.S.C. §119(e), this application claims priority to U.S. Provisional Application No. 60 / 848,971, filed October 3, 2006, which is hereby incorporated by reference in its entirety for all purposes.

[0003] incorporated by reference

[0004] According to 37 C.F.R. §1.52(e)(5), the sequence information contained on the file name: ATAP_Ma_2007PCT_SEQList_ST25.txt; size 31KB; created: October 3, 2007; application PatentIn-3.4, and Checker 4.4.0, which The entire contents are incorporated herein by reference. The data in the accompanying filed paper and computer readable sequence listings contain nothing new and are fully supported by priority application US Provisional Patent Application No. 60 / 848,971.

[0005] Statement Regarding Federally Funded Research

[0006] The US Government has certain rights in this invention due to the following grants: RO1-AG015556, RO1-CA95739, and RO1-HL69000, awarded by the National ...

Claims

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