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Method for controlling quality of euphorbia kansui decoction pieces

A decoction piece and content technology, which is applied in the field of quality control of traditional Chinese medicine kansui decoction pieces, can solve the problems of restricting research and development of kansui decoction pieces, difficult to ensure the safety and effectiveness of kansui decoction pieces, and achieves the effect of easy operation.

Inactive Publication Date: 2011-05-25
SHANGHAI UNIV OF T C M
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Problems solved by technology

The quality control of Gansui decoction pieces in "Chinese Pharmacopoeia" (2005 edition one) is mainly through powder identification and thin-layer chromatography identification, there is no content determination of index components or active ingredients, so it is difficult to ensure the safety and effectiveness of Gansui decoction pieces, and Limiting further research and development of Gansui

Method used

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  • Method for controlling quality of euphorbia kansui decoction pieces
  • Method for controlling quality of euphorbia kansui decoction pieces

Examples

Experimental program
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Effect test

Embodiment 1

[0018] (1) Take 8 batches of raw Gansui decoction pieces purchased from Shanghai, Anhui, Sichuan, Hebei, and Gansu, grind them into fine powder, weigh about 2g, weigh them accurately, add 10ml of chloroform, and ultrasonicate twice, each time for 15 minutes, Filtrate, combine the filtrates, evaporate to dryness, add chloroform to the residue to make up to 1ml, and obtain the test solution. Weigh 5 mg of 3-O-(2,3-dimethylbutyryl)-13-O-dodecanoyl ingenol reference substance, weigh it accurately, add methanol to dissolve and set the volume to the mark to prepare 1.00mg / ml reference substance solution. Precisely draw 20 μl of each of the above-mentioned reference substance solution and the test solution, inject them into a high-performance liquid chromatograph respectively, use octadecylsilane bonded silica gel as a filler, and use methanol-water as the mobile phase, and the gradient elution is (time / methanol percentage): 0 to 5 minutes / 70% to 85%, 5 to 55 minutes / 85% to 95%, the...

Embodiment 2

[0024] (1) Get 10 batches of Gansui decoction pieces purchased from Shanghai, Anhui, Hebei and the laboratory, and measure 3-O-(2,3-dimethylbutyryl) therein according to the method of Example 1(1) -13-O-lauroyl ingenol content. As a result, the content of 3-O-(2,3-dimethylbutyryl)-13-O-dodecanoylingenol in 10 batches of Gansui decoction pieces ranged from 0.27 to 0.92 mg / g.

[0025] (2) Take 10 batches of Gansui decoction pieces purchased from Shanghai, Anhui, Hebei and the laboratory, and determine the content of euphoradienol in it according to the method of Example 1 (2). As a result, the content of euphora in 10 batches of Gansui decoction pieces ranged from 1.49 to 4.5 mg / g.

[0026] It can be judged from this example that all 10 batches of Gansui decoction pieces purchased from Shanghai, Anhui, Hebei and the laboratory are qualified products.

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Abstract

The invention discloses a method for controlling quality of euphorbia kansui decoction pieces, which comprises a step of determining the content of 3-O-(2,3-dimethylbutanoyl)-13-O-oxododecyl ingenol and euphol in fresh and processed euphorbia kansui. The method uses the separated 3-O-(2,3-dimethylbutanoyl)-13-O-oxododecyl ingenol and euphol as indexes, establishes a method for detecting HPLC-ELSDfor controlling the quality of the euphorbia kansui decoction pieces, has simple and quick operation, and is applicable to quality control of the fresh euphorbia kansui and the processed euphorbia kansui decoction pieces.

Description

technical field [0001] The invention relates to a quality control method of Chinese medicine Gansui decoction pieces. Background technique [0002] In today's world, under the influence of the trend of "returning to nature", many countries are increasingly calling for natural medicines, and traditional Chinese medicine has been favored by the world for its rich resources, unique theoretical system, unique curative effect and low side effects. countries' attention. However, Chinese medicine contains complex ingredients, and the quality is difficult to stabilize due to the influence of various factors. Most Chinese medicines lack strict quality control methods and quality standards, so that they cannot meet the requirements of the international pharmaceutical market, which seriously restricts the development of my country's Chinese medicine industry. . Therefore, it has become an inevitable trend to combine traditional Chinese medicine with modern science and technology, esta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/36A61K125/00
Inventor 修彦凤施贝王海颖张永太丁文平王靖
Owner SHANGHAI UNIV OF T C M
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