Syphilis-diagnosis special multichannel micro-fluidic chip based on electrode modification technology

Abstract

The invention relates to a syphilis-diagnosis special multichannel micro-fluidic chip based on an electrode modification technology, belonging to the field of analytical testing. The quick and cheap diagnosis of syphilitic patients is one of the improved objectives of a relative diagnosis and treatment technology. The invention provides a micro-fluidic chip which points to the objective. The scheme is characterized in that pipelines with parallel structure are arranged in the chip, the parallel structure comprises four branched pipelines which are connected in parallel, four magnetic bead string working electrodes are respectively assembled in the four branched pipelines, each magnetic bead string working electrode comprises a magnetic bead string electrode and a gold size sensitive film, the gold size sensitive film is attached to the magnetic bead string electrode and is embedded with syphilitic specific antigens, and the gold size sensitive films arranged on the surfaces of the four magnetic bead string working electrodes are respectively embedded with four different syphilitic specific antigen materials of syphilitic specific antigens TP0684, TP 0453, TP 0821 and TP 0391. The micro-fluidic chip is beneficial to improving the syphilitic diagnostic efficiency.

Description

technical field [0001] The invention relates to a special multi-channel microfluidic chip for syphilis diagnosis based on electrode modification technology, which belongs to the field of analysis and testing. Background technique [0002] Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum (TP). Treponema pallidum only infects humans under natural circumstances, and humans are the only source of infection for syphilis, mainly through sexual contact. It can also be transmitted vertically through the placenta, causing congenital syphilis in the fetus. A small number of people can also be infected by blood transfusion. Since the 1980s, syphilis has revived again in my country. According to statistics from the National Center for STD Control, the annual growth rate of the incidence of syphilis in my country has reached 52.7%, and the incidence of congenital syphilis and neurosyphilis has increased significantly, and there is a gradual upward trend in ...

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Problems solved by technology

(4) At present, microfluidic sensors are mostly based on optical detection systems. The instruments are expensive and bulky, and full integration is difficult. Moreover, the detection cost is high, which limits its promotion.

[0006] At present, in the field of microfluidic chip technology, the related technologies and methods of using multiple specific antigens of syphilis to simultaneously detect and rapidly diagnose multiple syphilis antibodies have not been reported.

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