Soft capsule shell composition, soft capsule prepared from same and method for preparing soft capsule shell composition and soft capsule

A composition and soft capsule technology, applied in the field of soft capsule skin composition, can solve the problems of poor chewability, disintegration and dissolution delay, poor chewability and solubility, etc.

Active Publication Date: 2010-05-26
SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chewability and poor solubility are related to the composition of the softgel shell
[0003] Soft capsules currently on the market, especially vitami

Method used

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  • Soft capsule shell composition, soft capsule prepared from same and method for preparing soft capsule shell composition and soft capsule
  • Soft capsule shell composition, soft capsule prepared from same and method for preparing soft capsule shell composition and soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] The present invention is further illustrated below by way of examples. However, the scope of the present invention is not limited to these Examples. All reagents are commercially available unless otherwise noted.

[0028] Through the following preparation steps, according to the prescription in Table 1, taking vitamins A and D as examples, prepare 7 different vitamin AD soft capsules (the amount of each component is converted on the basis of 100kg capsule skin composition).

[0029] Table 1: Composition of different vesicular compositions

[0030] Element

Recipe 1

Formation 2

Party 3

Recipe 4

Recipe 5

Recipe 6

Recipe 7

gelatin

40％

40％

40％

40％

40％

40％

40％

glycerin

25％

18％

15％

12％

18％

12％

12％

Sorbitol

-

7％

5％

5％

5％

5％

3％

[0031] Element

Recipe 1

Formation 2

Party 3

Recipe 4

...

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Abstract

The invention provides a soft capsule shell composition which comprises the following components in percentage by weight: about 37-43 percent of gelatin, about 20-30 percent of plasticizer, about 1.5-3 percent of lysine and about 35-40 percent of water, wherein the plasticizer comprises the following components in percentage by weight: about 10-15 percent of glycerol, about 4-6 percent of sorbitol and about 6-9 percent of maltitol; wherein all the percentage of the components are all calculated relative to the total weight of the soft capsule shell composition. The invention also provides a soft capsule prepared from the soft capsule shell composition and a method for preparing the soft capsule shell composition and the soft capsule.

Description

technical field [0001] The present invention generally relates to soft capsule shell compositions, soft capsules prepared therefrom, and methods for preparing them. Background technique [0002] Soft capsule refers to a dosage form made by sealing a certain amount of drugs, active ingredients, nutrients, medicinal material extracts, etc., together with suitable auxiliary materials, into spherical, oval or other shaped soft capsules. For soft capsules, chewability and solubility, especially after long-term placement, are two important performance indicators. For example, vitamin AD soft capsules are currently the most important dosage form of vitamin AD preparations on the market, and their contents are vitamins A and D dissolved in cod liver oil or vegetable oil with adjusted concentrations. Vitamin AD soft capsule products currently on the market have problems such as poor chewability and / or reduced chewability, disintegration or dissolution delay during long-term storage....

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K9/48A61J3/07A61K47/10A61K47/18A61K47/26
Inventor 何淑旺陈伟刘长涛王凤英
Owner SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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