Azaindole derivatives as cftr modulators
A compound, heteroaryl technology, applied in the field of regulators, can solve problems such as increasing disease severity
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[0172] Table 2 below contains a listing of carboxylic acid synthesis materials that are commercially available or prepared by one of the methods described below.
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[0174]The mixture was stirred at 70°C overnight, then the reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and evaporated to dryness to yield crude 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanenitrile, which was used directly in subsequent steps. Step f: 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid [0007] converts 1-(2,2-difluoro- Benzo[1,3]dioxol-5-yl)-cyclopropanenitrile (crude product from previous step) was refluxed in 10% aqueous sodium hydroxide (50 mL) for 2.5 hours. The cooled reaction mixture was washed with diethyl ether (100 mL), and the aqueous phase was acidified to pH 2 with 2M hydrochloric acid. Filtration of the precipitated solid yielded 1-(2,2-difluo...
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