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Letrozole targeted slow-release transdermal patch and preparation method thereof

A technology for sustained-release transdermal and letrozole, applied in the field of medicine, can solve the problems of lack of targeting function, inability to prove sustained-release effect, etc., and achieve the effects of good permeability-promoting effect, enhanced curative effect, and increased drug concentration.

Inactive Publication Date: 2010-06-02
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent provides a new route of administration for the treatment of breast cancer with letrozole, there are still some deficiencies, mainly in the following points: (1) the invention only discloses the results of in vitro transdermal experiments, and cannot prove the Good sustained-release effect is also arranged in the body; (2) the letrozole transdermal drug delivery patch disclosed by the invention has no targeting function

Method used

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  • Letrozole targeted slow-release transdermal patch and preparation method thereof
  • Letrozole targeted slow-release transdermal patch and preparation method thereof
  • Letrozole targeted slow-release transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Letrozole 0.03g dissolved in 1.3g ethyl acetate, with 2g DURO- 87-2852 Mix well, apply evenly on the anti-adhesive layer, dry at 60°C for 10 minutes, then cover with a backing layer, punch out to a certain size and specification, and the product is ready.

Embodiment 2

[0025] Letrozole 0.03g dissolved in 1.3g ethyl acetate, with 2g DURO- 87-2677 Mix well, spread evenly on the anti-adhesive layer, dry at 60°C for 10 minutes, and then lay the backing layer on it, punch and cut it into a certain size and specification.

Embodiment 3

[0027] Letrozole 0.03g dissolved in 1.3g ethyl acetate, with 2g DURO- 87-4098 is fully mixed, evenly coated on the anti-adhesive layer, dried at 60°C for 10 minutes, and then covered with a backing layer, punched and cut into a certain size and specification.

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Abstract

The invention belongs to the technical field of medicine, and discloses a letrozole targeted slow-release transdermal patch and a preparation method thereof. The patch is a patch containing a novel sorbefacient, and can maintain the constant speed to release the medicament, thereby ensuring that the therapeutic effect is durably steady, prolonging the action time of the medicament, reducing administration times, and improving the compliance of patients. The patch is attached to the breast, so the medicament can enter mammary tissues through the skin, which remarkably improves the medicament concentration of letrozole in the ammary tissues and achieves better treatment effect. The patch and the preparation method have the advantages of simple preparation method, convenient use, good flexibility of the patch, and suitable adhesivity.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a letrozole targeted and localized sustained-release transdermal patch and a preparation method thereof. Background technique: [0002] According to statistics from the International Association Against Cancer, breast cancer is the malignant tumor with the highest incidence rate in women. Worldwide, 1.2 million women suffer from breast cancer each year, and 500,000 die from breast cancer. The lifetime probability of dying from advanced breast cancer in European women is 1 in 9. The incidence of breast cancer in my country is increasing year by year, especially in Shanghai, Beijing, Tianjin and coastal areas, which are the high incidence areas of breast cancer in China, and become the main killer of women's health. The characteristics of breast cancer in my country, in addition to the increasing incidence rate year by year, are significantly different from those in Western count...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4196A61P35/00A61P15/14
Inventor 方亮李丽徐新兰何仲贵
Owner SHENYANG PHARMA UNIVERSITY
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