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Grassleaf sweetflag rhizome extract, preparation method and application thereof

A technology of calamus calamus and its extract, which is applied in the field of extracts of calamus calamus and its preparation, can solve the problems of mutagenesis and carcinogenicity, and achieve the effects of high safety, low content, and improvement of learning and memory ability

Inactive Publication Date: 2010-06-09
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it has been reported in the literature that α, β-asarone may be carcinogenic and mutagenic

Method used

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  • Grassleaf sweetflag rhizome extract, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0034] The preparation of embodiment 1 Acorus calamus extract SCP-B

[0035] Take 200g of Acorus calamus, add 2L (2000g) of water to slightly boil (100°C) to extract twice, 1h each time, and filter the extract. Concentrate to 400ml, go up D101 type macroporous adsorption resin column, column volume is 200ml, and the consumption of macroporous adsorption resin is 1g Acorus calamus raw medicinal material / ml resin, respectively with 800ml water, 1000ml10% ethanol solution, 1000ml 20% ethanol solution, 1000ml of 30% ethanol solution was used for elution, the 20% ethanol eluate and the 30% ethanol eluate were collected, combined, concentrated and dried to obtain 4.3944g.

Embodiment 2

[0036] The preparation of embodiment 2 Acorus calamus extract SIPI-SCP

[0037] The Acorus calamus extract SCPB prepared in Example 1 was dissolved in the upper phase (the solvent system was chloroform-methanol-water=40%: 40%: 20%, percent by volume), the mobile phase was the lower phase, and the rotation speed was 800 rpm; The temperature is 25°C; the flow rate is 2.0ml / min, the peak after 350min is collected, concentrated and dried.

Embodiment 3

[0038] The preparation of embodiment 3 Acorus calamus extract SCP-B

[0039] Take 200g of Shichangpu medicinal material, add 1.6L (1600g) of water, extract 3 times at 90°C, 15 minutes each time, and filter the extract. Add methanol to the extract until the solution contains 60% methanol by volume, collect the precipitate, add 100ml of water to dissolve it, put it on a D101 macroporous adsorption resin column, the column volume is 500ml, and the consumption of the macroporous adsorption resin is 0.1g of Shichangpu raw medicinal material / ml resin, eluted with 1000ml water, 1000ml 5% ethanol solution, 1000ml 15% ethanol solution, 1000ml 35% ethanol solution respectively, collected 15% and 35% ethanol eluents, combined, concentrated and dried.

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Abstract

The invention discloses a method for preparing grassleaf sweetflag rhizome extract. The method comprises the following steps: extracting the grassleaf sweetflag rhizome by water; concentrating the extracting solution to obtain concentrated solution; leading the concentrated solution onto a non-polar macroporous adsorption resin column for gradient elution, wherein the elution gradient is from water to 35 percent aqueous solution of alcohol; collecting eluate of 15 to 35 percent aqueous solution of alcohol; and drying the eluate to obtain the grassleaf sweetflag rhizome extract. The invention also discloses the grassleaf sweetflag rhizome extract prepared by the method, and application of the extract in preparing a medicament and health-care products or foods for improving learning and memory ability, or application in preparing a medicament for treating alzheimer,s diseases. The grassleaf sweetflag rhizome extract has obvious effects of improving the learning and memory ability, has low content of toxic and side components alpha-asarone and beta-asarone and high safety, and provides new approach for preparing the medicament and the health-care products or the foods for improving the learning and memory ability and the medicament for treating the alzheimer,s diseases.

Description

technical field [0001] The invention relates to a calamus extract, a preparation method and application thereof. Background technique [0002] At present, the etiology of Alzheimer's disease (AD) is still unclear, so there is a lack of effective therapeutic drugs. Researchers at home and abroad are looking for therapeutic drugs in multiple links from pathological basis to symptomatic treatment. Chinese medical research workers are also in-depth research and development of new anti-Alzheimer's drugs. my country has extensive resources of traditional Chinese medicine, and there are many effective drugs that can improve learning and memory in the treasure house of traditional Chinese medicine in our country. Among these drugs, new drugs for the treatment of Alzheimer's disease may be developed. [0003] Shichangpu is one of the few aromatic and resuscitating herbs in traditional Chinese medicine. It is often used in traditional Chinese medicine formulas for refreshing the bra...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/00A61P25/28A23L1/29A23L1/30A23L33/105
Inventor 董文心杨培明顾丰华许海燕陈嘉倪翔陈佳张扬马东储奔红
Owner SHANGHAI INST OF PHARMA IND
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