Voglibose film and preparation method thereof

Abstract

The invention discloses a voglibose film and a preparation method thereof. The voglibose film comprises the following components by weight percent: 0.2-15% of voglibose, 40-99.8% of high molecular filming material, 0-20% of plasticizer, 0-5% of titanium pigment and 0-20% of flavouring agent, wherein the molecular weight of the high molecular filming material is 20000-300000. The invention is the voglibose film prepared by a solid dispersion technology, the medicine is highly dispersed in a carrier material and is encircled by the sufficient molecules of the carrier material, the high dispersivity of the medicine is ensured, the dissolving out of the medicine is quickened, the medicine enters the digestive tract along with saliva quickly, and the medicine effect is exerted.

Description

technical field

[0001] The invention relates to a voglibose preparation. Background technique

[0002] Diabetes is a condition in which blood sugar rises and there is sugar in the urine due to insufficient insulin in the body. Diabetes patients can be divided into insulin-dependent (type 1, namely IDDM) and non-insulin-dependent (type 2, namely NIDDM), and type 2 diabetes accounts for more than 80% of diabetic patients. At present, the treatment of type 1 diabetes is mainly insulin therapy; type 2 diabetes is treated with drugs, with the main goal of lowering blood sugar levels and alleviating symptoms. An important force emerging in the oral hypoglycemic drug market.

[0003] Voglibose is an α-glucosidase inhibitor. Its mechanism of action is to competitively inhibit maltase, isomaltase, glycosidase, etc. on the intestinal mucosa to reduce the decomposition of disaccharides to monosaccharides. It leads to a reduction in the formation of D-glucose, thereby delaying the di...

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