Compound of brain protein hydrolyzate and maleic acid and method for preparing same

Abstract

The invention provides compound of brain protein hydrolyzate and maleic acid and a method for preparing the same and also provides a method for preparing dispersible tablets of the medicinal compound of brain protein hydrolyzate and maleic acid, belonging to the technical field of the medicament. The medicinal compound of brain protein hydrolyzate and maleic acid is the peptidergic neural nutritional medicament specially used for the brain and can act on the central nervous system in various ways to adjust and improve the neuronal differentiation. The medicinal compound of brain protein hydrolyzate and maleic acid can promote the synthesis of the brain protein through a blood-brain barrier, has the efficacy of preventing hypoxia, improving the brain energy metabolism and providing neurotransmitter, peptide hormones and coenzyme precursors and can be used for preparing the medicament for improving insomnia, headache, memory loss, irritability and other symptoms, promoting the rehabilitation of acute cerebral infarction and acute brain injury and treating brain dysfunction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition made of cerebroprotein hydrolyzate and maleic acid, a preparation method thereof, and an application of the composition in preparing medicine for treating brain dysfunction. Background technique [0002] Brain dysfunction includes brain tissue ischemia and hypoxia injury, acute and chronic cerebrovascular disease, brain trauma, various toxic encephalopathy and other causes of cranial nerve dysfunction and memory loss, congenital brain hypoplasia, children's mental retardation , Alzheimer's disease, etc. Brain tissue is very sensitive to ischemia and hypoxia. With the aging trend of society and the prolongation of life expectancy, the incidence of hypoxic-ischemic cerebrovascular disease has increased significantly, seriously endangering human health and bringing heavy burdens to society and families. [0003] Cerebroprotein hydrolyzate ...

AI Technical Summary

Problems solved by technology

[0004] Patent CN200510103508 directly makes cerebroprotein hydrolyzate dispersible tablets from mammalian brain tissue extracts. The chemical properties of cerebroprotein hydrolyzate are unstable, and the active ingredients inside are easy to deteriorate, and it is not easy to store for a long time. It is directly made into dispersible tablets for pharmaceutical production. , storage and transportation have brought great inconvenience, cerebroprotein hydrolyzate should be relatively stable at a pH of 4-5, so it is easy to preserve it at this pH value

[0005] At the same time, as a drug that acts on the brain, the permeability of the blood-brain barrier is an important factor for drug activity. The brain targeting of the existing brain protein hydrolyzate is not ideal, and the amount of drug reaching the brain is limited, thus affecting its efficacy

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