Compound of brain protein hydrolyzate and maleic acid and method for preparing same
A technology of cerebroprotein hydrolyzate and maleic acid, which is applied in the field of medicine, can solve problems such as unstable chemical properties of cerebroprotein hydrolyzate, inconvenient drug production, storage and transportation, and unsatisfactory brain targeting, so as to ensure clinical drug use Safety, improve the ability to withstand hypoxia at normal pressure, and prolong the effect of entering the incubation period
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- Publication Date
- 2010-06-16
Smart Images
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition made of cerebroprotein hydrolyzate and maleic acid, a preparation method thereof, and an application of the composition in preparing medicine for treating brain dysfunction. Background technique
[0002] Brain dysfunction includes brain tissue ischemia and hypoxia injury, acute and chronic cerebrovascular disease, brain trauma, various toxic encephalopathy and other causes of cranial nerve dysfunction and memory loss, congenital brain hypoplasia, children's mental retardation , Alzheimer's disease, etc. Brain tissue is very sensitive to ischemia and hypoxia. With the aging trend of society and the prolongation of life expectancy, the incidence of hypoxic-ischemic cerebrovascular disease has increased significantly, seriously endangering human health and bringing heavy burdens to society and families.
[0003] Cerebroprotein hydrolyzate ...
Examples
Embodiment 1
[0071] The preparation of embodiment 1NM dispersible tablet
[0072] 1. Prescription:
[0073] 6.5mg (calculated by amino nitrogen): 14.4mg (calculated by total nitrogen) specifications
[0074] Protein hydrolyzate 148.0g
[0075] Maleic acid 14.8g
[0076] Microcrystalline Cellulose 116.0g
[0077] Sodium starch glycolate 30.0g
[0078] 50% ethanol appropriate amount
[0079] Magnesium Stearate 3.0g
[0080] Micronized silica gel 3.0g
[0081]
[0082] A total of 1000 tablets were prepared
[0083] 13mg (calculated by amino nitrogen): 28.8mg (calculated by total nitrogen) specifications
[0084] Protein hydrolyzate 296.0g
[0085] Maleic acid 29.6g
[0086] Microcrystalline Cellulose 232.0g
[0087] Carboxymethyl starch sodium 60.0g
[0088] 50% ethanol appropriate amount
[0089] Magnesium Stearate 6.0g
[0090] Micronized silica gel 6.0g
[0091]
[0092] A total of 1000 tablets were prepared
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