Compound of brain protein hydrolyzate and maleic acid and method for preparing same

A technology of cerebroprotein hydrolyzate and maleic acid, which is applied in the field of medicine, can solve problems such as unstable chemical properties of cerebroprotein hydrolyzate, inconvenient drug production, storage and transportation, and unsatisfactory brain targeting, so as to ensure clinical drug use Safety, improve the ability to withstand hypoxia at normal pressure, and prolong the effect of entering the incubation period

Active Publication Date: 2010-06-16
BEIJING SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent CN200510103508 directly makes cerebroprotein hydrolyzate dispersible tablets from mammalian brain tissue extracts. The chemical properties of cerebroprotein hydrolyzate are unstable, and the active ingredients inside are easy to deteriorate, and it is not easy to store for a long time. It is directly made into dispersible tablets for pharmaceutical production. , storage and transportation have brought great inco

Method used

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  • Compound of brain protein hydrolyzate and maleic acid and method for preparing same
  • Compound of brain protein hydrolyzate and maleic acid and method for preparing same
  • Compound of brain protein hydrolyzate and maleic acid and method for preparing same

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Example Embodiment

[0071] Example 1 Preparation of NM dispersible tablets

[0072] 1. Prescription:

[0073] 6.5mg (calculated as amino nitrogen): 14.4mg (calculated as total nitrogen)

[0074] Protein hydrolysate 148.0g

[0075] Maleic acid 14.8g

[0076] Microcrystalline cellulose 116.0g

[0077] Sodium starch glycolate 30.0g

[0078] 50% ethanol appropriate amount

[0079] Magnesium stearate 3.0g

[0080] Micro powder silica gel 3.0g

[0081]

[0082] 1,000 tablets in total

[0083] 13mg (calculated as amino nitrogen): 28.8mg (calculated as total nitrogen)

[0084] Protein hydrolysate 296.0g

[0085] Maleic acid 29.6g

[0086] Microcrystalline cellulose 232.0g

[0087] Sodium starch glycolate 60.0g

[0088] 50% ethanol appropriate amount

[0089] Magnesium stearate 6.0g

[0090] Micro powder silica gel 6.0g

[0091]

[0092] 1,000 tablets in total

[0093] 2. Specific steps:

[0094] (1) Take the cerebroprotein hydrolysate composition, maleic acid, sodium star...

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Abstract

The invention provides compound of brain protein hydrolyzate and maleic acid and a method for preparing the same and also provides a method for preparing dispersible tablets of the medicinal compound of brain protein hydrolyzate and maleic acid, belonging to the technical field of the medicament. The medicinal compound of brain protein hydrolyzate and maleic acid is the peptidergic neural nutritional medicament specially used for the brain and can act on the central nervous system in various ways to adjust and improve the neuronal differentiation. The medicinal compound of brain protein hydrolyzate and maleic acid can promote the synthesis of the brain protein through a blood-brain barrier, has the efficacy of preventing hypoxia, improving the brain energy metabolism and providing neurotransmitter, peptide hormones and coenzyme precursors and can be used for preparing the medicament for improving insomnia, headache, memory loss, irritability and other symptoms, promoting the rehabilitation of acute cerebral infarction and acute brain injury and treating brain dysfunction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition made of cerebroprotein hydrolyzate and maleic acid, a preparation method thereof, and an application of the composition in preparing medicine for treating brain dysfunction. Background technique [0002] Brain dysfunction includes brain tissue ischemia and hypoxia injury, acute and chronic cerebrovascular disease, brain trauma, various toxic encephalopathy and other causes of cranial nerve dysfunction and memory loss, congenital brain hypoplasia, children's mental retardation , Alzheimer's disease, etc. Brain tissue is very sensitive to ischemia and hypoxia. With the aging trend of society and the prolongation of life expectancy, the incidence of hypoxic-ischemic cerebrovascular disease has increased significantly, seriously endangering human health and bringing heavy burdens to society and families. [0003] Cerebroprotein hydrolyzate ...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/20A61P9/10A61P25/00A61K31/191
Inventor 郭维城车冯升孟宪慧贾中新霍彩霞
Owner BEIJING SIHUAN PHARMA
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