Alpha-conotoxins from Hainan province for specific blockage of acetylcholine receptor and application thereof

A conotoxin and specific technology, applied in the field of α-conotoxin peptides produced in Hainan, can solve the problems that research and development have not yet been carried out
CN101745097AInactive Publication Date: 2010-06-23HAINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HAINAN UNIVERSITY
Publication Date
2010-06-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to alpha-conotoxins from Hainan province for specific blockage of a acetylcholine receptor and application thereof, in particular to application of alpha-conotoxins LtIA for specific blockage of (alpha)2(beta)3. nAChRs, application of alpha-conotoxins TxIB for specific blockage of (alpha)9(beta).10 nAChRs, related pharmaceutical compositions and the like.
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Description

technical field

[0001] The present invention relates to Hainan-produced α-conotoxin peptide capable of specifically blocking acetylcholine receptors (nAChRs) and its use. nAChRs are key receptors with important physiological functions and clinical research significance, mediating many physiological functions of the central and peripheral nervous systems, including learning, memory, response, analgesia and motor control. Background technique

[0002] Nicotinic acetylcholine receptors (nAChRs), which have important physiological roles and clinical research significance, mediate many physiological functions of the central and peripheral nervous systems, including learning, memory, response, analgesia, and motor control. nAChRs activate the release of various neurotransmitters such as dopamine, norepinephrine, serotonin, and γ-aminobutyric acid. It has been confirmed that nAChRs are the key targets for the screening, diagnosis and treatment of a large class of drugs for importa...

Claims

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