Preparation process for extracting emodin from rheum officinale by using supercritical CO2

Abstract

The invention relates to a preparation process for extracting emodin from rheum officinale by using supercritical CO2. The process comprises the following steps: purifying and grinding Chinese medicinal rheum officinale serving as a raw material, sieving the smashed rheum officinale by using a 40-mesh screen, collecting siftage, filling the pre-processed rheum officinale powder into an extraction kettle of supercritical CO2 extraction equipment, filling entrainer into the reaction kettle to submerge the rheum officinale powder, performing extraction by using the supercritical CO2 as an extractant for 300 minutes at the extraction temperature of between 30 and 50 DEG C and the extraction pressure of between 15 and 30 MPa, and collecting an extraction oil; introducing the obtained product into a separation kettle to perform separation under the conditions of the separation pressure I of 9 MPa, the separation temperature I of 30 DEG C, the separation pressure II of 6 Mpa and the separation temperature II of 30 DEG C; setting the pressures of a steel bottle and a storage tank to more than or equal to 4 MPa; collecting the product in the separation kettle at a pumping frequency of 20 F, and decompressing, spraying and drying the product to obtain emodin powder. The weighing and detection show that the emodin extract yield is over 15 percent; and the specification of the emodin is 0.35 g / grain and the content reaches 6.6 to 10 m / grain. In the invention, the optimal technical parameters are obtained by a scientific method according to the specific conditions of the rheum officinale, so the product quality and amount are greatly improved; no oxidation nor thermal degradation occurs in the extraction process and the product has no residual organic solvent, so the extraction is complete and the mouth feel is good; and the preparation process is pollution-free and therefore is environmentally-friendly extraction technology.

Description

technical field [0001] The invention relates to a preparation process for extracting emodin from rhubarb, a traditional Chinese medicine, in particular to a process using supercritical CO 2 Preparation process of extracting emodin from rhubarb. Background technique [0002] Rhubarb This product is the dry root and rhizome of Rheum palmatum L., R.tanguticum Maxim.ex Balf. or R.officinale Baill. of Polygonaceae. Mainly produced in Gansu, Qinghai, Tibet, Sichuan. Medicinal rhubarb is mainly produced in Sichuan, Guizhou, Yunnan, Hubei, and Shaanxi. Rhubarb is one of the four commonly used traditional Chinese medicines. Rhubarb has the functions of purging heat and dredging intestines, cooling blood and detoxification, and removing blood stasis and dredging menstruation. Traditionally, it is mostly used as a laxative to treat constipation caused by dry stools and hot knots. Rhubarb is contained in most lipid-lowering, weight-loss, detoxification and beauty-enhancing tradition...

AI Technical Summary

Problems solved by technology

The traditional methods for extracting emodin from rhubarb include solvent extraction or acid hydrolysis followed by alkali neutralization, etc. These methods are complicated to operate, prone to oxidation, thermal degradation, and residual organic solvents in the product, which affects product quality

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