Anti-tumor medicinal composition and application and preparation method thereof
A technology of composition and medicine, which is applied in the field of anti-tumor pharmaceutical composition and its application and preparation, and can solve problems such as no literature reports
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Embodiment 1
[0014] Gongshan lanceolata (Cephalotaxus lanceolata K.M.Feng ex Cheng et L.K.Fu) plant characteristics: Gongshan lanceolata (C.lanceolata) is produced along the Dulong River in Gongshan, Yunnan, in the broad-leaved forest at an altitude of 1900 meters, and it is rarely scattered. Gongshan three-pointed fir is an arbor, up to 20 meters high, 40 cm diameter at breast height, purple skin, smooth; branchlets drooping. Thin leathery leaves, arranged in two rows, lanceolate, 4.5-10 cm long, 4-7 mm wide, long pointed at the apex, widest at the base, rounded; dark green on the leaf surface, raised midrib, white stomata on the underside of the leaf . The seeds are obovate-elliptic, 3.5-4.5 cm long, the aril is greenish-brown when mature, and the peduncle is 1.5-2.0 cm long. The fruiting period is November. Three-pointed fir in Gongshan is similar to three-pointed fir, but the leaves of three-pointed fir are leathery, lanceolate, lobular-shaped at the base, and the middle and lower pa...
Embodiment 2
[0023] The tumor cytotoxic activity of compound SHC-10 of the present invention:
[0024] The present invention finds that the compound SHC-10 isolated from Gongshan Sanjianshan has significant tumor cell inhibitory activity, especially the cytotoxic activity against gastric cancer SGC7901, and is compatible with the clinical chemotherapy drug cisplatin for the treatment of gastric cancer and the famous natural drug 10-hydroxyl for the treatment of gastric cancer. Compared with the positive control drug of camptothecin, the inhibitory activity was more significant (see Table 1).
[0025] Table 1 Cytotoxic activity of compound SHC-10 (IC 50 in μM)
[0026]
[0027] As can be seen from the data in Table 1: the cytotoxic biological activity (IC 50 inμM) is very obvious: the inhibitory activity IC of the compound SHC-10 on the above three tumor cell lines 50 , were 1.16, >40, and 0.66 μM respectively; while the inhibitory activity ICs of the positive control compounds cispl...
Embodiment 3
[0037] Tablet: 10 mg of the compound SHC-10 obtained in Example 1, 180 mg of lactose, 55 mg of starch, and 5 mg of magnesium stearate;
[0038] Preparation method: mix the compound, lactose and starch, moisten it evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, then press the mixture into tablets, each tablet weighs 250mg, and the compound content is 10mg .
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