Preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris

Abstract

The present invention discloses a preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris. In order to overcome the defects of the traditional taste modifying process for preparing the sugar-free oral liquid, the present invention adopts the beta-cyclodextrin inclusion technique to modify taste, develops a sugar-free oral liquid specification, realizes the industrialization of the production process of the Chinese medicine oral liquid to which the inclusion technique is applied, improves the taste of the preparation, improves the medicine use compliance of patients, ensures the clinical efficacy of the product, and simultaneously, increases the water-solubility of low-polarity active components by the formation of an inclusion compound, and improves the quality stability of the preparation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of a sugar-free traditional Chinese medicine oral liquid for treating angina pectoris of coronary heart disease. Background technique [0002] Angina pectoris of coronary heart disease is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional excitement or other factors increase myocardial oxygen consumption. During the onset of angina pectoris, ECG often shows temporary ST segment changes or accompanied by T wave changes. Coronary angiography shows coronary artery stenosis. [0003] Coronary heart disease is the most common heart disease clinically, with an incidence rate of 3-4%, and its mortality rate accounts for about 20% of cardiovascular disease deaths. With the acceleration of the pace of work and life of the...

AI Technical Summary

Problems solved by technology

[0010] The existing preparation specifications of Xintong Oral Liquid only have sugar-containing type, and there is no sugar-free type, which brings some adverse effects to the clinical use of the drug by patients who also suffer from diabetes. In order to better serve the clinic and develop clinical drug targets, It is urgent to develop sugar-free Xintong Oral Liquid

However, during the research process, it was found that the taste of the sugar-free preparation would be very poor if it was not flavored, which would be unacceptable to patients. However, the use of common flavorings has the following disadvantages:

[0011] 1) It can only increase the sweetness, but cannot improve the peculiar smell brought by the seafood medicinal materials in the prescription;

[0012] 2) A slight increase in the amount of stevia will bring a bitter aftertaste;

[0013] 3) Other chemically synthesized low-calorie flavoring agents such as sodium cyclamate and aspartame have poor flavoring effects and certain safety hazards, and aspartame is sterilized and degraded, resulting in reduced sweetness and degradation Harmful to the human body and other issues

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