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Allicin liposome for resisting microbe, protozoan and tumor and preparation method thereof

An allicin lipid and antimicrobial technology, which is applied in the direction of antineoplastic drugs, liposome delivery, medical preparations of non-active ingredients, etc., can solve problems that cannot be overcome by western medicine, and achieve the effect of solving difficult diseases

Inactive Publication Date: 2010-08-04
沈德铭 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the present invention has hydrophilic and lipophilic properties, so the application of allicin is extended from anti-bacteria and fungi to anti-virus, anti-protozoa and tumor, and it is expected to solve the problems that cannot be overcome by western medicine

Method used

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  • Allicin liposome for resisting microbe, protozoan and tumor and preparation method thereof

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Effect test

Embodiment Construction

[0039] A kind of allicin liposome that is used for antimicrobial, protozoa and tumor, it comprises each component of following amount:

[0040] Allicin, 1-6.5ml;

[0041] Co-solvent, 10-50ml;

[0042] Medicinal soybean oil, add to 100ml.

[0043] The co-solvent is one of Tween-80 and Tween-100.

[0044] Described a kind of allicin liposome that is used for antimicrobial, protozoa and tumor, the content of described each component is as follows:

[0045]

Allicinml

Co-solvent ml

Medicinal soybean oil ml

mg per capsule

Example 1

3

30

67

10

Example 2

4.5

45

50.5

15

Example 3

6.5

65

28.5

20

[0046] The preparation method of described allicin liposome, it comprises the following steps:

[0047] Step 1, slowly pour the co-solvent into the container containing allicin according to the ratio, and keep stirring;

[0048] Step 2, keep stirring, add soybean oil until the ...

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Abstract

The invention relates to an allicin compound and a preparation method of the preparation of the allicin compound. An allicin liposome for resisting microbe, protozoan and tumor comprises the following components in every 100ml of solution : 1-6.5ml of allicin, 10-50ml of cosolvent and the balance of medicinal bean oil, wherein the cosolvent is one selected from Tween-80, Tween-100 or lecithin. A preparation method of the allicin liposome comprises the following steps of: firstly, slowly pouring the cosolvent into a container filled with the allicin according to the proportion, and continuously stirring; secondly, keeping stirring, and adding bean oil to ensure that the total volume reaches 100ml; and thirdly, split charging into 300 soft capsules or gelatin pearls. The compound has hydrophilic and oleophilic characteristics so that the application of the allicin is expanded to resisting virus, protozoan and tumor from resisting bacteria and epiphyte, and the invention is hopeful to solve the problem which can not be overcome by western medicines.

Description

technical field [0001] The invention relates to a medicinal composition, in particular to a preparation method and application of an allicin composition and its preparation. Background technique [0002] Allicin was artificially synthesized in 1976 and has been used clinically for 30 years, but it is still in the scope of antibacterial and antifungal. The reason is that the general formula of the main component of allicin is R-S n -R, wherein R is an unsaturated hydrocarbon, n=1-4. Its structure makes it insoluble in water, and the polyether bond is irritating (toxic) to the human body. The immune system of the human body cannot distinguish it from pathogenic microorganisms and kill it by mistake, resulting in a decline in drug efficacy. Therefore, it has not been promoted in the antiviral, antiprotozoal and antitumor fields. [0003] And recent studies have shown that allicin is a broad-spectrum antimicrobial drug, and various reports have mentioned that it is effective ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/10A61K47/44A61P31/00A61P33/02A61P35/00A61K47/24A61K47/26
Inventor 沈德铭沈沪生
Owner 沈德铭
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