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Preparation process and products of oridonin fine particles

A technology of oridonin A and fine particles is applied in the production of bulk chemicals, organic chemistry, drug combination and other directions, which can solve the problems of vascular inflammation and pain in patients, achieve convenient medication, reduce use costs and toxic side effects, and produce short cycle effect

Inactive Publication Date: 2010-08-11
CHINA NAT ACAD NANOTECH & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, since this ingredient is insoluble in water, conventional injections mostly rely on the addition of surfactants or organic solvents to improve solubility, and long-term intravenous infusion can easily cause side effects such as vascular inflammation and pain in patients

Method used

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  • Preparation process and products of oridonin fine particles
  • Preparation process and products of oridonin fine particles
  • Preparation process and products of oridonin fine particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] Example: A preparation process of oridonin fine particles, characterized in that it includes the following steps:

[0028] (1) Configure oridonin solution: fully dissolve oridonin in the organic solvent according to the ratio of organic solvent: oridonin at 100:2, so that the concentration of oridonin is 2.0 %, the dissolution temperature is controlled at 40℃;

[0029] (2) Connect the oridonin solution 1 prepared in step (1) with the solution pump 2, and control the working pressure to 15MPa;

[0030] (3) Carbon dioxide feed: the CO in the cylinder 2 9 Enter the supercritical fluid anti-solvent equipment system through the booster pump valve 8, and enter the crystallization kettle 4, the flow rate is controlled at 10ml / min, the starting temperature is controlled at 45°C; the pressure is 15MPa;

[0031] (4) The oridonin solution configured in the above step (1) is rapidly sprayed into the crystallization kettle 4 through the solution pump 2 through the nozzle 3 in the supercriti...

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Abstract

A preparation process of oridonin fine particles is characterized by comprising the following steps: (1) preparing oridonin solution; (2) connecting the oridonin solution prepared in the step (1) with a solution pump; (3) charging carbon dioxide; (4) jetting the oridonin solution into a crystallization reactor by a nozzle in a supercritical fluid anti-solvent equipment system through the solution pump; and (5) separating out the oridonin crystals. The oridonin fine particles prepared by the process are characterized in that the particles are loose amorphous white superfine powder; and the particle size d (0.5) is 5.135um. The process is suitable for the superfine oridonin powder, improves the medicine dissolution and the curative effects and is used for preparing the oridonin fine particles by applying the supercritical fluid crystallization technology.

Description

(1) Technical field: [0001] The invention relates to a process for preparing oridonin fine particles, in particular to a process for preparing oridonin fine particles and products thereof. (2) Background technology: [0002] As far as drugs are concerned, the size of the particles can directly affect the degree of drug absorption and efficacy. Generally speaking, the smaller the drug particles, the larger the specific surface area, the easier it is to dissolve in the body fluids of the human body, and can be more completely absorbed by the human body, thus having a good effect. Larger particles of drugs have a higher dissolution rate. Slow, it is difficult to be fully absorbed and utilized to achieve the desired efficacy. [0003] In the prior art, the refinement of drug particles is usually achieved by crushing method, ball milling method, solution method, and supercritical fluid crystallization technology. However, the particle size distributions obtained by the first two metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61P35/00
CPCY02P20/54
Inventor 魏海郭震张俊
Owner CHINA NAT ACAD NANOTECH & ENG
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