Garlic oil enteric pellet capsule and preparation method thereof

A technology of enteric-coated pellets and garlic oil, which is applied in the direction of capsule delivery, oil/fat/wax non-active ingredients, etc., can solve the problems of poor stability, easy degradation, and long residence time of the main drug, so as to ensure effectiveness and stability Sexuality, high bioavailability, and the effect of improving water solubility

What is AI technical title?
AI technical title is built by PatSnap AI team. It summarizes the technical point description of the patent document.
A technology of enteric-coated pellets and garlic oil, which is applied in the direction of capsule delivery, oil/fat/wax non-active ingredients, etc., can solve the problems of poor stability, easy degradation, and long residence time of the main drug, so as to ensure effectiveness and stability Sexuality, high bioavailability, and the effect of improving water solubility

CN101804145BActive Publication Date: 2012-11-14HAINAN PULIN PHARMA

1 Cites 0 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.

Viewing Examples

Smart Image

Examples

Experimental program

Comparison scheme

Effect test

Embodiment 1

[0028] Example 1: In this example, garlic oil enteric-coated pellet capsules were prepared, and the following prescription was adopted:

[0029] Vegetarian Pill Prescription:

[0030]

[0031] Coating prescription:

[0032] Shellac 149.2g, add 1500ml 95% ethanol, stir overnight to dissolve completely, set aside;

[0033] Isolation gown: 20g PVP, 6.7g talcum powder, add 500ml 95% ethanol to dissolve, suspend, set aside.

[0034] Concrete preparation process steps are as follows:

[0035] a. Take the prescription amount of vegetarian pill auxiliary materials, add 95% ethanol to fully suspend, add garlic oil, stir for 30 minutes, add TW-80 and continue stirring for more than 30 minutes, set aside;

[0036] b. Take the pellet core and place it in the pill making machine, feed the pellets and make pellets, and the parameters are controlled as follows:

[0037] Speed 350rpm. The temperature is 24dec, the spraying is 25, and the air volume is high;

[0038] C. Take the pel...

Embodiment 2

[0043] Embodiment 2: the present embodiment adopts following prescription:

[0044] Vegetarian Pill Prescription:

[0045]

[0046] Coating prescription:

[0047] Acrylic resin 149.2g, add 1500ml 95% ethanol, stir overnight to dissolve completely, set aside;

[0048] Isolation gown: 20g PVP, 6.7g talcum powder, add 500ml 95% ethanol to dissolve, suspend, set aside.

[0049] Process is identical with embodiment 1.

Embodiment 3

[0050] Embodiment 3: the present embodiment adopts following prescription:

[0051] Vegetarian Pill Prescription:

[0052]

[0053] Coating prescription:

[0054] Shellac 149.2g, add 1500ml 95% ethanol, stir overnight to dissolve completely, set aside;

[0055] Isolation gown: 20g PVP, 6.7g talcum powder, add 500ml 95% ethanol to dissolve, suspend, set aside.

[0056] Process is identical with embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

PUM

Login to View More

Abstract

The invention relates to the field of antibacterial agent, in particular to a garlic oil enteric pellet capsule and a preparation method thereof. Wherein the garlic oil pellet capsule is composed of a coated pellets and a coating layer, the coated pellets comprises pharmaceutically active ingredients of garlic oil and coated pellet minor ingredient; wherein the coated pellet minor ingredient comprises pellet core, bonding agent, absorbing agent, disintegrating agent, antioxygen agent and antiplastering aid while the coating layer comprises an enteric coating and an isolated layer; the coated pellet comprises the following components according to weight percentage: 5-40% of garlic oil, 10-60% of pellet core, 2-10% of binding agent, 20-50% of absorbing agent, 0.5-5% of antioxygen agent, 0.5-10% of disintegrating agent and 2-20% of antiplastering aid.Compared with the existing allicin dosage form, the garlic oil enteric pellet capsule of the invention enjoys more advanced dosage form, thus ensuring effectiveness and stability of the capsule and high bioavailability; in addition, with the enteric pellet capsule of the invention, harm done to gastric mucosa as the capsule is dissolved inside the stomach is avoided and the allicin is not damaged by gastric acid so that drug effect of the capsule is not affected.

Description

technical field [0001] The invention relates to the field of antibacterial drug preparations, in particular to a garlic oil enteric-coated pellet capsule and a preparation method thereof. Background technique [0002] Allicin (Allicin), also known as allicin, chemical name diallyl trisulfide (CH2=CH2CH22S2S2S2CH22CH=CH2), is a volatile oily substance extracted from the spherical bulb of garlic, and is the main active ingredient of garlic. In addition to garlic's traditional antibacterial, antiviral, and antiprotozoal effects, allicin has been proven by modern medicine to have antitumor, lower blood lipids, and improve body immunity. It is known as "natural broad-spectrum antibiotics". Pure allicin The bactericidal effect of garlic is 100 times that of penicillin. In today's situation where antibiotics are abused and antibacterial properties are continuously enhanced, garlic oil is considered to be an ideal and safe alternative. In recent years, scholars at home and abroad h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

Application Information

Patent Timeline

14 Nov 2012

Publication

CN101804145B

IPC: A61K9/48; A61K125/00; A61K47/44

Inventors: 范敏华; 李绍贤