Oral spray or aerosol containing Palonosetron

Abstract

The invention relates to an oral spray or aerosol containing Palonosetron, which comprises Palonosetron or other medical salt thereof and auxiliary materials which are acceptable on pharmacy and are selected from buffer, flavoring agent, antiseptic, chelating agent, polar solvent or non-polar solvent. The active components in the spray or the aerosol can be rapidly absorbed through mucous menbrane of mouth to take effect rapidly, and has high bioavailability.

Description

field of invention The invention relates to an oral spray or an aerosol, especially an oral spray or an aerosol containing palonosetron or a pharmaceutically acceptable salt thereof. In this formulation, the active ingredient can be quickly absorbed through the oral mucosa to act quickly and have high bioavailability. Background of the invention Aerosols and sprays are formulated products that spray their contents onto the site of application through a specific container device. Among them, aerosol refers to a preparation made by packaging medicine and a suitable propellant in a pressure-resistant sealed container with a special valve system. When used, the content is sprayed out by the pressure of the propellant. The mist aerosol can be in the form of smoke, foam or trickle, and can generally be used for respiratory inhalation, skin and mucous membrane medication. With the continuous improvement of aerosol dosage forms and the continuous increase in the scope of applicat...

AI Technical Summary

Problems solved by technology

These two dosage forms are commonly used dosage forms of the drug, and the preparation process is mature, but there are many inconveniences in use: injections usually need to be used in hospitals and administered by nurses with professional skills, and injection administration is traumatic administration way, which will easily reduce the compliance of patients with medication; the tablet is absorbed through the gastrointestinal tract after oral administration, and for some special patients, especially the weak and elderly after chemotherapy, it is inconvenient to swallow and take, and it will cause gastric irritation. Intestinal discomfort, when there are vomiting symptoms that need to be treated and overcome, the absorption and efficacy of the drug are usually affected by the vomiting of the pills taken

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