Active fragment of anti-opioid peptide

An active fragment, anti-opioid peptide technology, applied in the direction of DNA/RNA fragments, peptides, peptide sources, etc., can solve the problem of tolerance to acupuncture and the limited effective rate of acupuncture analgesia, reduce the dosage of morphine, easily The effect of being degraded and easily synthesized
CN101817877BInactive Publication Date: 2011-09-14PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2011-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses an active fragment of an anti-opioid peptide and an antagonistic peptide and application thereof. The anti-opioid peptide is one of the following amino acid residue sequences: 1) SEQ ID No: 1 in a sequence list; 2) SEQ ID No: 3-5; and 3) a polypeptide which has an antagonistic morphine damage resisting function and is formed by substituting, deleting or adding one to ten amino acid residues in the amino acid residue sequence of SEQ ID No: 1 and SEQ ID No: 3-5 in the sequence list. The antagonistic peptide is one of the following amino acid residue sequences: 1) SEQ ID No: 9-11 in the sequence list; and 2) a polypeptide which has functions of enhancing morphine analgesis, reversing morphine resistance and / or weakening or eliminating withdrawal symptoms and is formed by substituting, deleting or adding one to ten amino acid residues in the amino acid residue sequence of SEQ ID No: 9-11 in the sequence list. The anti-opioid peptide and the active fragment and antagonistic peptide of the anti-opioid peptide can play important roles in the field of medicine or the field of the preparation of rehabilitation medicaments and have wide application prospect.
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Description

[0001] This application is a divisional application with the application number 200710118104.2, the filing date is June 28, 2007, and the invention title is "an anti-opioid peptide, its antagonistic peptide and the application of the antagonistic peptide". technical field

[0002] The present invention relates to peptides and their coding genes and applications, in particular to an anti-opioid peptide and its antagonistic peptide which can antagonize the antinociceptive effect of morphine, and the antagonistic peptide can enhance morphine analgesia, reverse morphine tolerance and / or or in drugs that reduce or eliminate the effects of withdrawal symptoms. Background technique

[0003] As we all know, rampant drug trafficking and drug use around the world has become a cancer that endangers society, seriously interfering with orderly economic construction and social stability. In addition, intravenous drug use has also caused a rise in the infection rate of AIDS populations. At...

Claims

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