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Painless automatic anesthesia apparatus

An automatic and anesthetic technology, applied in automatic injectors, syringes, infusion sets, etc., can solve problems such as restricting the degree of automation of anesthesia equipment

Active Publication Date: 2010-10-20
SHANDESHI MEDICAL TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art about anesthesia equipment, although anesthesia implementation equipment, such as infusion devices, has been automated, it generally requires the operator to select specific operating parameters from the applicable effective range to start the anesthesia process
This restricts the degree of automation of anesthesia equipment

Method used

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  • Painless automatic anesthesia apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]

[0046] Taking the painless abortion operation as an example, the applicable range of the target concentration for propofol as an anesthetic will be described below.

[0047] The experimenter of the present invention collected the parameters of 97 subjects in each stage of the painless artificial abortion operation, and applied the NONMEM (nonlinear mixed-effect modeling) program to establish a propofol-based pharmacodynamic model. Then select age (AGE), height (HG), weight (WT) as covariates and use stepwise regression method to establish the population pharmacodynamic model of the drug.

[0048] Among them, 97 patients who underwent painless artificial abortion were recorded and selected: age (between 18-55 years old, average 30.6), weight (between 41-80 kg, average 54.3), height (between 150-172 cm, average 161); At the same time, the subject's induction concentration, loss of consciousness concentration, time of loss of consciousness, maintenance concentration, c...

Embodiment 2

[0065]

[0066] After selecting an appropriate number of individuals as sampling samples, and using the above-mentioned pharmacodynamic model of propofol as an anesthetic, the value of the target concentration can be obtained through calculation and derivation:

[0067] EC50=1.85μg / ml

[0068] EC75 = 2.18 μg / ml

[0069] EC90=2.70μg / ml

[0070] EC95 = 3.22 μg / ml

[0071] Among them, EC50 is the drug target concentration when the drug efficacy intensity reaches half of the maximum drug efficacy intensity, EC75 is the drug target concentration when the drug efficacy intensity reaches 75% of the maximum drug efficacy intensity, and EC90 is the drug concentration when the drug efficacy intensity reaches 90% of the maximum drug efficacy intensity. Drug target concentration, EC95 is the drug target concentration when the drug efficacy intensity reaches 95% of the maximum drug efficacy intensity. For the mode of anesthesia for gastroscopy, the recommended target concentration is ...

Embodiment 3

[0073]

[0074] After selecting an appropriate number of individuals as sampling samples, and using the pharmacodynamic model of propofol as described above, it can be deduced that

[0075] EC50=2.04μg / ml

[0076] EC75 = 2.31 μg / ml

[0077] EC90=2.61 μg / ml

[0078] EC99 = 3.42 μg / ml

[0079] Among them, EC50 is the drug target concentration when the drug efficacy intensity reaches half of the maximum drug efficacy intensity, EC75 is the drug target concentration when the drug efficacy intensity reaches 75% of the maximum drug efficacy intensity, and EC90 is the drug concentration when the drug efficacy intensity reaches 90% of the maximum drug efficacy intensity. Drug target concentration, EC99 is the drug target concentration when the drug efficacy intensity reaches 99% of the maximum drug efficacy intensity. For the mode of anesthesia for colonoscopy, the recommended target concentration is EC99 = 3.42 μg / ml.

[0080] (Regarding the control process to achieve the targe...

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Abstract

The invention relates to a painless automatic anesthesia apparatus, which comprises an anesthetic injection execution unit, a control unit and an input unit, wherein the anesthetic injection execution unit is used for injecting anesthetic, i.e. propofol into the body of a patient; the control unit is electrically connected with the anesthetic injection execution unit and is used for controlling the dosage of propofol injected by the anesthetic injection execution unit through preset parameters according to external input; and the input unit is electrically connected with the control unit and is used by an operator for inputting an anesthesia mode and target weight, and / or selecting anesthetic target concentration and / or starting or stopping anesthetic injection process. The control unit is set in a way that the target concentration of the input propofol for an abortion operation mode is 2.17 mug / ml-4.38 mug / ml; the target concentration of the input propofol for a gastroscopy mode is 1.85 mug / ml-3.22 mug / ml; and the target concentration of the input propofol for an enteroscopy mode is 2.04 mug / ml-3.42 mug / ml. When the target concentration is determined and maintained, the external injection speed of the anesthetic is also determined and is stable.

Description

technical field [0001] The invention relates to a medical anesthesia equipment, in particular to an anesthesia device which can automatically select a suitable mode according to the patient's individual condition information to input anesthesia agent and complete the anesthesia process. Background technique [0002] The popularization and application of anesthetics such as propofol (propofol) in medicine is of great significance, which not only effectively alleviates the pain of patients, but also facilitates the smooth progress of surgical treatment. [0003] Generally speaking, anesthesia for patients requiring surgery basically depends on the operating experience and skills of the operating physician, which requires the anesthesia operator to judge the specific physical condition of the individual based on experience and select the appropriate parameters such as input volume, concentration, and input speed. Obviously, traditional anesthesia methods cannot meet the needs o...

Claims

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Application Information

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IPC IPC(8): A61M5/20
Inventor 李民关雷
Owner SHANDESHI MEDICAL TECH BEIJING
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