Palladium coordination compound for antitumor drugs

Abstract

The invention belongs to the field of pharmaceutical science, and relates to a palladium coordination compound for antitumor drugs. The structural formula of the palladium coordination compound is shown in the specification, wherein a substituent group N-N is independently selected from aliphatic diamine or substituted aliphatic diamine, aromatic diamine and various substituted aromatic diamine; and an R1 or R2 is independently selected from substituted or unsubstituted branched chains and linear chain or cyclic annular aliphatic hydrocarbon, aryl groups, and nonaromatic or aromatic heterocycle groups.

Description

Technical field: The invention belongs to the field of pharmacy, and relates to a palladium complex and its application in treating cancer. Background technique: Cancer has become one of the main threats to human health, and it is showing a clear upward trend. Cancer has become the most important cause of death in the United States, and the cancer mortality rate ranks first among all causes of death in cities in my country. Therefore, my country has listed the research of anticancer drugs as one of the most important strategic issues in the development of new drugs, and researching new anticancer drugs with high efficiency, low toxicity and high selectivity has become a long-term goal and task for drug researchers. Today, cisplatin has become one of the three most widely used drugs in the treatment of cancer in the world. Although the application of cisplatin is successful, there are many disadvantages at the same time. The use of it will produce severe kidney, nerve and na...

AI Technical Summary

Problems solved by technology

But so far, there have been no reports on the anticancer activity of sulfonylated deprotonated amino acid dianions / diamine palladium complexes at home and abroad.

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