3-(1-halogenated methylene) sulphur chromane-4-ketone compound as well as preparation method and application thereof

Abstract

The invention discloses a 3-(1-halogenated methylene) sulphur chromane-4-ketone compound shown as a formula (I) as well as a stereoisomer, a racemic or non-racemic mixture of the stereoisomer or a pharmaceutically acceptable salt or solvate, a preparation method, a pharmaceutical composition and antibacterial and anticancer application thereof.

Description

technical field The patent of the present invention relates to 3-(1-halogenated methylene) thiochroman-4-one compounds, in particular to substituted 3-(1-halogenated methylene) thiochroman-4-one compounds and Its preparation and antibacterial and anticancer uses. Background technique Fungi are eukaryotic organisms that have a similar structure and physiological metabolic process to host cells. According to the different infection sites caused by fungi, they can be divided into superficial fungal infections and deep fungal infections. Superficial fungal infections are mainly caused by various tinea fungi, such as tinea pedis, tinea capitis, tinea corporis, etc. Currently, greymycin, nystatin, and ketoconazole are often used as therapeutic drugs. Deep fungal infection is harmful and even life-threatening. It is mainly caused by pathogenic fungi including Candida albicans, Cryptococcus neoformans, Aspergillus, and Mucormyces. Under normal circumstances, fungi that do not caus...

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Problems solved by technology

Although a lot of research on anticancer drugs has been carried out at present, such as cisplatin, vinblastine, vincristine, camptothecin, and its derivatives, paclitaxel and a series of anticancer active drugs have been discovered, but there is no good activity and low toxicity. Or non-toxic broad-spectrum or narrow-spectrum anticancer drugs appear

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