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Immune modulation via C-type lectin

An immune response and antigen technology, applied in immunoglobulin, anti-animal/human immunoglobulin, allergic diseases, etc., can solve problems such as unknown binding specificity correlation

Inactive Publication Date: 2010-11-24
CANCER RES TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for most NK lectin receptors, their binding specificities and relevance in NK or DC function are unknown

Method used

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  • Immune modulation via C-type lectin
  • Immune modulation via C-type lectin
  • Immune modulation via C-type lectin

Examples

Experimental program
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Embodiment

[0245] Sequence and structure of CLEC9a

[0246] A search of the NCBI gene database revealed that CLEC9a sequences have been identified in mice (Mus musculus), apes (Pan troglodytes), humans (Homo sapiens) and rhesus monkeys (Macaca mulatta). A blast search using the mouse CLEC9a protein sequence also revealed predicted CLEC9a proteins in rat (Rattus norvegicus), dog (Canis familiaris) and bovine (Bostaurus). The human cDNA sequence and its representative protein sequence with related domains are in figure 1 described in detail. The mouse cDNA sequence and its representative protein sequence that we cloned from mouse CD8α+DC are in figure 2 in detail. This sequence differs from the published cDNA sequence in that it contains an additional G residue, causing a frameshift to the end of the molecule, resulting in a relatively figure 2 Longer proteins shown in . Our sequence appears to be correct as it matches the published genome sequence (NC_000072.4GI:94471533); as seen ...

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Abstract

The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

Description

technical field [0001] The present invention relates to the regulation of the immune system, in particular the use of molecules with affinity for CLEC9a molecules to elicit and suppress immune responses against target antigens. Background technique [0002] The immune system is able to detect the presence of infectious agents and mount a response against them without destroying its own tissues. This phenomenon is unusual due to the great molecular diversity of pathogens and their high replication and mutation rates. Multicellular organisms have been motivated to develop a variety of different immune recognition systems during the evolution process, namely "innate" and "adaptive" immune systems. [0003] The evolutionarily ancient innate immune system detects the presence and nature of infection, provides the first line of host defense, and controls the initiation and determination of the adaptive immune system's effector classes. [0004] Dendritic cells (DCs) play a pivot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/705C07K16/28A61K38/00A61K47/00C07K14/47A61K39/00
CPCC07K16/2878A61K2039/57C07K16/2851A61K39/0005A61K2039/507C07K2316/95A61K2039/6056C07K2317/55C07K2319/33C07K2316/96C07K2317/75C07K2317/74C07K2317/76A61K47/6811A61P1/00A61P1/16A61P11/00A61P11/06A61P19/02A61P25/00A61P3/10A61P31/12A61P35/00A61P37/00A61P37/04A61P37/06A61P9/00A61K39/4644A61K2239/57A61K39/4611A61K39/0011
Inventor 大卫·桑乔-马德里德奥利弗·舒尔茨尼尔·查尔斯·罗杰斯卡埃塔诺·雷斯埃索萨丹尼尔·彭宁顿奥利维耶·皮埃尔·若弗里
Owner CANCER RES TECH LTD
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