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Application of pharmaceutical composition containing ACEI and B vitamins in preparing medicine for treating peripheral artery diseases

A technology for peripheral arterial disease and B vitamins is applied to a pharmaceutical composition containing an angiotensin converting enzyme inhibitor and B vitamins, and the application field of preparing a drug for treating peripheral arterial disease can solve the problems of easy recurrence, atypical symptoms, Difficulty in treatment

Inactive Publication Date: 2010-12-01
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most patients with PAD are asymptomatic, but the consequences of PAD are serious, including intermittent claudication, amputation, ruptured abdominal aortic aneurysm, severe hypertension, renal failure, and incidence of myocardial infarction (MI) stroke and cardiac death increased, and the 10-year risk of death is 6 times that of non-PAD patients
The symptoms of PAD are atypical, difficult to treat, easy to relapse, and seriously endanger human health and quality of life.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0015] The pharmaceutical composition containing 5 mg of enalapril maleate and 5 mg of folic acid is used for preparing medicine for treating peripheral arterial disease.

no. 2 example

[0017] The pharmaceutical composition containing enalapril maleate at a content of 10 mg and folic acid at a content of 0.4 mg is used for preparing medicine for treating peripheral arterial diseases.

no. 3 example

[0019] The pharmaceutical composition containing enalapril maleate at a content of 40 mg and folic acid at a content of 0.2 mg is used for preparing medicine for treating peripheral arterial disease.

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PUM

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Abstract

The invention relates to an application of a pharmaceutical composition containing angiotensin converting enzyme inhibitor (ACEI) and B vitamins in preparing a medicine for treating peripheral artery diseases. The pharmaceutical composition of the invention not only can treat the peripheral artery diseases, but also has a curative effect on hypertension caused by the peripheral artery diseases, simultaneously enhances the protective action of the angiotensin converting enzyme inhibitor on target organs, and reduces the incidence of complications such as myocardial infarction, cerebral apoplexy, heart failure, kidney failure, and the like.

Description

technical field [0001] The invention relates to the application of a pharmaceutical composition, in particular to the application of a pharmaceutical composition containing an angiotensin-converting enzyme inhibitor and B vitamins as a medicine for treating peripheral arterial diseases. Background technique [0002] Peripheral artery disease (PAD) refers to the narrowing, occlusion or tumor-like expansion of the aorta and its branches other than the coronary arteries, and is a manifestation of systemic atherosclerosis. Most patients with PAD are asymptomatic, but the consequences of PAD are serious, including intermittent claudication, amputation, ruptured abdominal aortic aneurysm, severe hypertension, renal failure, and incidence of myocardial infarction (MI) stroke and cardiac death increased, and the risk of death within 10 years was 6 times that of non-PAD patients. The symptoms of PAD are atypical, difficult to treat, easy to relapse, and seriously endanger human heal...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P9/10A61P9/12
Inventor 靳晴陈光亮徐希平
Owner 北京奥萨医药研究中心有限公司