Implantable membrane-covering three-dimensional carrier and preparation method thereof
A carrier and membrane technology, applied in the direction of prosthesis, medical science, etc., can solve serious problems, patients' secondary repair pain, tissue repair effects and other problems, achieve simple preparation process, avoid immune response and rejection, and not easily degraded Effect
Active Publication Date: 2012-12-19
SHENZHEN BEIKE BIOTECH
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Problems solved by technology
[0002] With the manifestation of the value of stem cells in clinical practice, the problem of transplantation immunity has become the main difficulty limiting the clinical application of stem cells. How to carry out allogeneic cell transplantation without significant immune rejection is a hot topic that needs to be solved urgently in the application of stem cells. In recent years, In the past, people used three-dimensional carriers to culture transplanted cells. Sodium alginate, collagen, gelatin, etc. were used as cell support materials, and a layer of polylysine or chitosan was used as a coating. growth, and can grow and proliferate through the exchange of small molecule substances with the outside world by coating, which provides a good idea for the in vitro culture of cells, but in animal experiments and clinical experiments, due to polylysine or chitosine The sugar will be gradually degraded by the organism, and the support material and cells in the cyst will still be in direct contact with the biological tissue, resulting in an immune response or rejection, which will affect the tissue repair, and the patient may need secondary repair or cause pain more serious, with a huge economic burden on individuals and society
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[0039] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.
[0040] like figure 1 , figure 2 As shown, the present invention provides an implantable three-dimensional carrier of the membrane, comprising a carrier body 2 and a carrier film 1, the carrier body 2 is wrapped in the carrier film 1; the carrier body 2 includes a biological matrix 4 and an active substance 3; the carrier body 2 is spherical, columnar or irregular; the thickness of the carrier film 1 is 0.1--3mm.
[0041] The active substance 3 is a cell, or an active protein factor, or a combination of cells and an active protein factor. The cells include stem cells, progenitor cells and adult cells of various tissues, namely: islet cells, hematopoietic stem cells, mesenchymal stem cells, neural stem cells, endothelial progenitor cells, umbilical cord blood stem cells, umbilical cord blood mononuclear cells, and retinal cells; The active pr...
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Abstract
The invention provides an implantable membrane-covering three-dimensional carrier and a preparation method thereof. The carrier comprises a carrier body and a carrier membrane, wherein the carrier body comprises a biological matrix and an active substance, and the carrier body is wrapped in the carrier membrane. The carrier membrane does not affect free exchange of small molecules, but can prevent the exchange of cells and macromolecular protein so as to ensure that the carrier is not easily degraded. The carrier has a simple, economic and practical structure, and can effectively avoid immunological reaction and exclusive reaction generated in a transplanting process.
Description
【Technical field】 [0001] The invention relates to the technical field of biological carriers, in particular to an implantable three-dimensional carrier and a preparation method thereof. 【Background technique】 [0002] With the manifestation of the value of stem cells in clinical practice, the problem of transplantation immunity has become the main difficulty limiting the clinical application of stem cells. How to carry out allogeneic cell transplantation without significant immune rejection is a hot topic that needs to be solved urgently in the application of stem cells. In recent years, In the past, people used three-dimensional carriers to culture transplanted cells. Sodium alginate, collagen, gelatin, etc. were used as cell support materials, and a layer of polylysine or chitosan was used as a coating. growth, and can grow and proliferate through the exchange of small molecule substances with the outside world by coating, which provides a good idea for the in vitro cultur...
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IPC IPC(8): A61L27/50A61L27/18A61L27/20A61L27/16A61L27/54A61L27/38A61L27/24A61L27/22
Inventor 吴世凯阳小卫姜舒郑意端胡祥
Owner SHENZHEN BEIKE BIOTECH