Enterovirus and application thereof

A technology for enterovirus and hand, foot and mouth disease, applied in antiviral agents, viruses/bacteriophages, medical preparations containing active ingredients, etc., which can solve health hazards for infants and young children

Inactive Publication Date: 2010-12-08
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the disease has been reported before, it mostly appeared as sporadic cases. In 2009, it broke out in many areas of Anhui, Henan and Hebei in my country, causing serious harm to the health of infants and young children.

Method used

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  • Enterovirus and application thereof
  • Enterovirus and application thereof
  • Enterovirus and application thereof

Examples

Experimental program
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Embodiment 1

[0013] Embodiment 1, the acquisition of Enterovirus EV71 type (Enterovirus 71) Henan isolate 2

[0014] 1. Isolation of Enterovirus 71 (Enterovirus 71) Henan isolate 2

[0015] The inventor of the present invention collects the serum sample of the hand, foot and mouth disease patient through clinical identification, then carries out virus isolation, and the method sample of virus isolation is directly inoculated in Vero cell, and when cytopathic change reaches 95%, collects virus culture supernatant, after three After rounds of plaque purification, pick a single plaque, infect Vero cells to proliferate the virus, collect the cell suspension, and obtain the virus liquid. Finally, the inventor isolated an enterovirus EV71 virus from samples collected in Henan Province, and the The enterovirus EV71 virus was named Enterovirus EV71 (Enterovirus 71) Henan isolate 2. Then the virus characteristics and pathogenicity were studied.

[0016] Enterovirus 71 (Enterovirus 71) Henan isola...

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PUM

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Abstract

The invention discloses an enterovirus and application thereof. The enterovirus has a name: Henan isolates 2 of an EV (Enterovirus) 71 type and has a preservation registration number CGMCC No. 3675. The enterovirus has stronger pathogenicity and can be used for establishing an animal model of hand, foot and mouth diseases and developing vaccines.

Description

technical field [0001] The invention relates to a strain of enterovirus and its application. Background technique [0002] Hand-foot-mouth disease (HFMD) is a common infectious disease caused by a variety of enteroviruses. In recent years, there have been frequent outbreaks in tropical areas of the Asia-Pacific region, mainly in infants and young children. Enteroviruses causing HFMD include enterovirus EV71 (Enterovirus 71, Enterovirus 71, referred to as EV-71), group A Coxsackie virus (CoxA), Echo virus (Echo) and the like. Among them, EV-71 is the main pathogen causing HFMD, which often leads to severe neurological syndromes. EV-71 is a single-stranded positive-sense RNA virus, which is divided into three genotypes, A, B, and C, and eight subtypes, B1-B4 and C1-C4. [0003] Although the disease had been reported before, it mostly appeared as sporadic cases. In 2009, it broke out in many areas of Anhui, Henan and Hebei in my country, causing serious harm to the health of ...

Claims

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Application Information

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IPC IPC(8): C12N7/00A01K67/027A61K39/125A61P31/14
Inventor 常国辉吴晓燕林磊罗彦军祝庆余
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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