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Medical composite containing pirfenidone and preparation method thereof

A technology of pirfenidone and pirfenidone tablets, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems that pirfenidone has not been listed for sale. , to achieve the effect of benefiting the drug effect, reducing human intolerance, and high concentration

Active Publication Date: 2012-09-26
BEIJING KAWIN TECH SHARE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no pirfenidone on the market in China

Method used

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  • Medical composite containing pirfenidone and preparation method thereof
  • Medical composite containing pirfenidone and preparation method thereof
  • Medical composite containing pirfenidone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: preparation of pirfenidone tablet (0.2g / sheet)

[0026] Prescription: Pirfenidone 200g

[0027] Microcrystalline Cellulose 56g

[0028] Sodium carboxymethyl starch 20g

[0029] Hypromellose 6g

[0030] Magnesium Stearate 3g

[0031] 1000 pieces

[0032] Take by weighing 20g of sodium carboxymethyl starch and the pirfenidone and microcrystalline cellulose of prescription quantity and pulverize respectively, pass through 80 mesh sieves for subsequent use respectively; The raw and auxiliary materials that will pulverize are taken by prescription quantity and mix evenly for standby; Use distilled water to distill the material Make soft material, granulate with 20 mesh sieve, dry at 50-60°C; granulate through 20 mesh sieve, add the prescribed amount of magnesium stearate, and finally mix; measure the content of intermediates, determine the weight of the tablet, and compress the tablet; The plain tablet is coated ...

Embodiment 2

[0033] Embodiment 2: preparation of pirfenidone tablet (0.2g / sheet)

[0034] Prescription: Pirfenidone 200g

[0035] Microcrystalline Cellulose 56g

[0036] Sodium carboxymethyl starch 10g+10g

[0037] Hypromellose 6g

[0038] Magnesium Stearate 3g

[0039] 1000 pieces

[0040] Take by weighing 10g of sodium carboxymethyl starch and place it at 105°C for drying for 5 hours for later use; weigh 10g of sodium carboxymethyl starch and the prescribed amount of pirfenidone and microcrystalline cellulose to pulverize respectively, and pass through 80 mesh sieves respectively for later use; The raw and auxiliary materials are weighed according to the prescription amount and mixed evenly for later use; add distilled water to make the material into soft material, granulate with a 20-mesh sieve, and dry at 50-60°C; Sodium carboxymethyl starch, final mixing; measure the content of intermediates, determine the weight of the tablet, and ...

Embodiment 3

[0041] Embodiment 3: preparation of pirfenidone tablet (0.4g / sheet)

[0042] Prescription: Pirfenidone 400g

[0043]

[0044] Weigh 20g sodium carboxymethyl starch and put it in 105°C for drying for 5 hours for later use; weigh 20g sodium carboxymethyl starch and the prescription amount of pirfenidone and carboxymethyl cellulose to pulverize respectively, pass through 80 mesh sieve respectively for later use; Good raw and auxiliary materials are weighed according to the prescription quantity and mixed evenly for later use; add distilled water to make the material into a soft material, granulate with a 20-mesh sieve, and dry at 50-60°C; sort through a 20-mesh sieve, and add the prescription quantity of magnesium stearate and 20g sodium carboxymethyl starch, final mixing; Measure the content of intermediates, set the tablet, and compress it; The above-mentioned plain tablet is coated (coating layer weight gain 3%-5%).

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Abstract

The invention provides a medical composite containing pirfenidone, which is characterized by containing 20-90% of pirfenidone, 10-50% of filler, 1-10% of disintegrating agent, 0.1-8% of adhesive and 0.2-3% of lubricant.

Description

[0001] The invention relates to a pirfenidone medicinal composition and a preparation method of the composition. technical background: [0002] Idiopathic pulmonary fibrosis (IP F) is a common disease all over the world, and its morbidity and mortality have increased in the past 10 years. It is estimated that the number of patients suffering from IPF in the United States, Europe and Japan is about 220,000 , of which there are 90,000 IPF patients in the United States. IPF is comparable in prevalence to diseases such as chronic myelogenous leukemia (CML). The disease is a progressive disease. The development of secondary pulmonary fibrosis is relatively slow, and the development of pulmonary fibrosis can stop after removal of the cause caused by external causes. Pulmonary fibrosis is a disease of the respiratory system. In addition to the fibrosis of interstitial diseases of the lung itself, pulmonary fibrosis can be formed due to damage to the lung interstitium by diseases of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4418A61K47/38A61P11/00
Inventor 杨成
Owner BEIJING KAWIN TECH SHARE HLDG