Medicament for vaginal irrigation
A technique of vaginal douching and medicine, which is applied in the direction of medicine combination, antibacterial medicine, pharmaceutical formula, etc., can solve the problems of human body stimulation, achieve the effect of protecting the physiological environment, good therapeutic effect and reducing stimulation
Inactive Publication Date: 2010-12-15
NANJING MESE PHARMA
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AI Technical Summary
Problems solved by technology
[0004] However, the acidity of the above-mentioned polycresol solution is too strong, and the stimulation to the human body is relatively large, so it can only be used for local burning treatment, and can not be directly used for vaginal douching
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0013] In 120g concentration of 50% (weight) polycresol sulfonaldehyde solution, add 880g distilled water, fill after stirring evenly, check. A polycresol solution with a concentration of 6% and a pH of 4.6 was prepared.
Embodiment 2
[0015] In the 50% (weight) polycresol sulfonal solution with a concentration of 80 g, add 920 g of distilled water, stir evenly, fill and check. Prepare a 4% polycresol solution with a pH of 5.0.
Embodiment 3
[0017] In 160g of 50% (weight) polycresol solution, add 840g of distilled water, stir evenly, fill and check. Prepare a polycresol solution with a concentration of 8%, and a pH of 1.5.
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The invention provides a medicament for vaginal irrigation, which is policresulen solution of which the concentration expressed in percentage by weight is 4 to 8 percent. The invention also provides the application of the medicament. The medicament has the advantage that: the pH value of the medicament is closer to the acid environment in vagina, wherein the pH value of a healthy vagina of a human body is about 4.0 to 4.6 and the healthy vagina is in weak acid, so that the medicament can reduce stimulation to the human body and protect the physiological environment of the vagina; in addition, the medicament is directly used for vaginal irrigation, can effectively prevent kinds of pathogenic bacteria, fungi and the like, so that the medicament has good treatment effect on diseases such as cervicitis, vaginal infections (such as leucorrhoea increasing caused by bacteria, trichomonad and mould, and the like) or pruritus vulvue and the like.
Description
technical field [0001] The invention relates to a medicine directly used for vaginal washing, in particular to a polycresol solution directly used for vaginal washing. Background technique [0002] Polycresol has a broad-spectrum antibacterial effect, including common Gram-positive bacteria, Gram-negative bacteria, molds and viruses, among which Gardnerella Vaginatis, anaerobic bacteria, Trichomonas and Candida are particularly sensitive to it; but Doderlein Vaginal Flore (vaginal Lactobacillus flora) is basically not affected. Its pharmacological action mechanism is: killing bacteria, mold and trichomonas through high acid and protein coagulation, selectively causing necrosis or diseased tissue and columnar epithelial protein denaturation, causing vasoconstriction and plasma protein coagulation to stop bleeding. At present, there is no report of polycresol sulfonal causing drug resistance. Polycresol has a selective coagulation and exclusion effect on necrotic or diseased...
Claims
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IPC IPC(8): A61K31/795A61P15/02A61P15/00A61P31/04A61P31/10
Inventor 季刚王殿广赵萍
Owner NANJING MESE PHARMA
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