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Encapsulated hydrophobic actives via interfacial polymerization

An active ingredient, hydrophobic technology for use in personal care compositions

Inactive Publication Date: 2012-11-28
DOW GLOBAL TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, encapsulation required high shear and / or solvent exchange steps

Method used

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  • Encapsulated hydrophobic actives via interfacial polymerization
  • Encapsulated hydrophobic actives via interfacial polymerization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Exemplary encapsulated hydrophobic actives of the present invention contain the components described in Table 1.

[0059] Table 1

[0060]

[0061] Mix A component. For example, emulsify component B using a Silverson Model L4RTA with a 2-1 / 4 inch high shear emulsification head. Add A slowly to B while mixing eg at 1000-1500 rpm. The mixing speed is then increased until the droplet size is about 0.5 microns less than the desired final particle size, which speed is hereinafter referred to as the "desired droplet velocity". C was then added dropwise at a mixing speed ("C mixing speed") that was 1000-2000 rpm lower than the desired droplet speed. The mixing speed was then reduced again to a relatively slow speed, and the mixture was stirred for 3-4 minutes, after which the mixing speed was increased back to C mixing speed, and D, E, and F were added. Afterwards, the mixture was stirred for 3-4 minutes, the composition comprising OMC particles encapsulated by an inte...

Embodiment 2

[0063] Exemplary sunscreen bases contain the components described in Table 2.

[0064] Table 2

[0065]

[0066] Combine A and place in an oven at about 80°C until the solid ingredients have dissolved. A was then removed from the oven and cooled to below about 40°C. B is combined, then A and B are combined, preferably homogenized, eg by using an IKA mixer.

Embodiment 3

[0068] Formulations prepared essentially according to the above protocol in Examples 1 and 2 were prepared and combined with comparative components as in Table 3 to provide sunscreen compositions:

[0069] table 3

[0070] Batch 3 (comparison) Batch 4 Batch 1 -- 31％ DDS 621 emulsified OMC 9.55％ -- Batch 2 18.05％ 18.05％ CARBOPOL 940 carboxyvinyl polymer 0.2％ 0.2％ water 72.2％ 50.75％

[0071] The order of addition was: base sunscreen (batch 2) mixed with batch 1 or DDS 621 emulsified OMC (Dow Chemical Company) and CARBOPOL polymer, then mixed with water.

[0072] For 10 panelists, 0.05 g of each sample was applied to designated areas on their right or left forearm. Initially, each sample was evaluated for spreadability, absorption to the skin, smoothness, stickiness, greasiness, moist feel, and overall skin feel, and then re-evaluated 1 hour later for moist feel, oiliness, skin smoothness, and skin feel. ...

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PUM

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Abstract

The present invention provides personal care compositions, as well as methods for protecting low viscosity hydrophobic liquid actives.

Description

technical field [0001] The present invention relates to personal care compositions. Background technique [0002] Many personal care compositions contain water insoluble or hydrophobic active ingredients. These active ingredients can impart an oily feel to the composition. This is undesirable since sensory perception is a key sales driver in the personal care market. In addition, there are health concerns associated with the unfavorable sensory perception of sunscreens or other beneficial personal care compositions, for example, where the feel of the product results in underutilization. [0003] In addition to irritation and sensory challenges, a previous challenge for sunscreen formulators has been the instability of avobenzone to light. One strategy to overcome these challenges is to sequester or encapsulate hydrophobic active ingredients. In the past, encapsulation required high shear and / or solvent exchange procedures. Accordingly, what are needed are improved metho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/11A61K8/84A61Q17/04
CPCA61K8/84A61Q17/04A61K8/11
Inventor 罗伯特·B·弗莱彻戴维·L·马洛特基张晓东
Owner DOW GLOBAL TECH LLC
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